Published Paper Details:

Cocrystal is a concept in which the drug and coformer lives in same structure. It is formulation which is gaining the more attention from researchers of pharmaceutical and chemical sciences. Cocrystals increases the physiochemical properties of the drug. During the preparation of the pharmaceutical product, it is necessary to increase the physicochemical properties of active pharmaceutical ingredients. Pharmaceutical cocrystals can be employed to improve many physicochemical characteristics of a drug that contains solubility, dissolution, bioavailability and stability of pharmaceutical compounds while maintaining its therapeutic activity. It is very advantageous and easy process for production of pharmaceutical compounds. The preparation of polymorphic forms, solvates, hydrates and salts of cocrystals during the synthesis are also increases the properties. The rules and processes like hydrogen bonding rules, solubility, screening through the CSD database and thermodynamic characteristics can be utilized for the rational design of cocrystals and selection of coformers for synthesis multi-component cocrystals. In this paper, we discuss with the synthesis, strategic aspects of formulation, design, and characteristics of cocrystals along perspectives on its regulatory and intellectual property considerations.