Published Paper Details:

The oral route is the most preferred drug administration path because to its ease of administration, convenience, high patient compliance, flexibility in dosage form design, fewer sterility constraints, and cost effectiveness. Lipid emulsions, lipid solutions, micro emulsions, and dry emulsions are examples of lipid drug delivery systems. Artemether (ARM), a poorly water soluble chemical, presents difficulties in developing pharmaceutical formulations with adequate bioavailability. Capmul MCM was used as the oil, Tween 80 as the surfactant, and PEG 400 as the co-surfactant in various ratios to create four self micro-emulsifying formulations. Using an adsorption method, optimised liquid SMEDDS formulations were converted into free-flowing powder and evaluated for drug content, FTIR, DSC, Globule size analysis, SEM, and in-vitro dissolution study. The results show that decreased crystallinity, altered surface morphology, and smaller globules were responsible for a significant increase in drug dissolving rate from the modified S-SMEDDS formulation.