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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
DYSFUNCTIONAL NLRP1 LEADS TO COMPROMISED IMMUNE RESPONSE AND INCREASED SUSCEPTIBILITY TOWARDS VARIOUS DISEASES
Authors
Janhavi Dhore, Gwayn Fernandes, Ravindran Mugesh, Snehashish Sanyal, Anusha Bailoor
Keywords
NLRP1, Dysfunction, Innate Immunity, Inflammasome, Interleukin IL-1, Caspase-1, V939M
Abstract
The study delineates effect of a polymorphism in NLR family pyrin domain containing 1 (NLRP1) protein which causes dysfunction, leading to a compromised immune response resulting in increased susceptibility of the host towards the foreign pathogenic infections. NLRP1 inflammasome promotes the activation of interleukin IL-1, IL-18, IL-33 which are effective mediators of inflammatory innate immune response to tissue damage and pathogen invasion. The retrieval of SNPs of the NLRP1 gene has been carried out through dbSNP. The deleterious SNPs were discerned using the computational tools SIFT, I-MUTANT, PhD-SNP and PROVEAN. The SNP V939M of NLRP1 was predicted to be the most deleterious on the basis of the outcomes from the computational tools. The protein structure of NLRP1 was retrieved from PDB (Protein Data Bank) and the structural mutations were carried out in Pymol. (patchdock)
IJCRT's Publication Details
Unique Identification Number - IJCRT2106164
Paper ID - 208404
Page Number(s) - b335-b347
Pubished in - Volume 9 | Issue 6 | June 2021
DOI (Digital Object Identifier) - http://doi.one/10.1729/Journal.27222
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Janhavi Dhore, Gwayn Fernandes, Ravindran Mugesh, Snehashish Sanyal, Anusha Bailoor, "DYSFUNCTIONAL NLRP1 LEADS TO COMPROMISED IMMUNE RESPONSE AND INCREASED SUSCEPTIBILITY TOWARDS VARIOUS DISEASES", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.9, Issue 6, pp.b335-b347, June 2021, Available at :http://www.ijcrt.org/papers/IJCRT2106164.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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