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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 12 | Issue 5 | Month- May 2024
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Paper Title
PROMOTER HYPERMETHYLATION OF GENES IN AGING
Authors
Manisha Verma, Tushar Kumar, Neeraj, Runjhun Mathur, Fanish Kumar Pandey, Abhimanyu Kumar Jha
Keywords
Promoter Hypermethylation of Genes In Aging
Abstract
Hypermethylation is an important process of gene regulation. Gene silencing through methylation occurs through the activity of DNA methyltransferases, enzymes that transfer a methyl group from S-adenosyl-L-methionine to the carbon 5 position of cytosine. DNA methylation levels and aging are strongly linked. The general trend seems to be the establishment of global hypomethylation and regions of CpG-island hypermethylation with age. Speculatively, this overall decrease in 5mC content could lead to less efficient gene regulation, and the CpG island hypermethylation could cause inappropriate silencing of specific genes. Aging and age-related diseases include defined changes in 5-methylcytosine content and are generally characterized by genome-wide hypomethylation and promoter-specific hypermethylation. In this review promoter hypermethylation in different aging genessuch as GSTP1,p16, p14 RASSF1A,ESR1,GSTP1,NKX2-5 and APC has been discussed.
IJCRT's Publication Details
Unique Identification Number - IJCRT2106059
Paper ID - 208290
Page Number(s) - a403-a410
Pubished in - Volume 9 | Issue 6 | June 2021
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Manisha Verma, Tushar Kumar, Neeraj, Runjhun Mathur, Fanish Kumar Pandey, Abhimanyu Kumar Jha, "PROMOTER HYPERMETHYLATION OF GENES IN AGING", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.9, Issue 6, pp.a403-a410, June 2021, Available at :http://www.ijcrt.org/papers/IJCRT2106059.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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