Published Paper Details:

Diatoms are microalgae that live in the houses made of the glass which is made of silica wall. Diatoms are the only organisms on the planet whose cell wall is composed of opaline silica which is transparent. The Diatomaceous earth, which is a substance that composed of the fossil of diatoms which is used in the filters, for insulation purpose, paints, as a base in the dynamite and abrasives like products. This review is based on the role of diatoms in the cancer drug delivery. The capacity to specifically kill such cancer cell that are large in populations while leaving solid cells which is unaffected is a critical objective in anticancer therapies and its treatment. The utilization of nano- porous material which is silica-based substance used as drug delivery method and used as vehicles which has recently proven and very successful method, yet creation of these materials requires exorbitant and toxic synthetics. Microalgae-determined nano- porous biosilica from diatoms are used to deliver chemotherapy drugs or medications to the cancer cells of the organisms that suffer from cancer. The species of diatom like Thalassiosira and Phaeodactylum is well defined and genetically designed to show an IgG-binding domain of the protein G which is present on the biosilica surface of the diatom which, empowering the connection of cell which targeting on the antibodies. The Neuroblastoma and the B-lymphoma cells that are specifically well being targeted and killed by the biosilica showing explicit antibodies which sorbed with drug loaded nanoparticles. The treatment with the exact similar biosilica prompts tumor growth relapse in a subcutaneous mouse xenograft which is a method where the mice is the model of neuroblastoma. Therefore, it is observed that hereditarily designed biosilica frustules might be utilized as flexible 'backups' for the targeted delivery of ineffectively water-dissolvable anticancer drugs to the tumor specific sites.