Published Paper Details:

Background: Ca breast is the most common malignancy among women in the world. The receptor status of breast cancer including ER, PR and HER-2 Neu play a crucial role in planning the management of the disease. Aims: Assessment of the hormone receptor (ER, PR and HER-2-Neu) expression in carcinoma breast is the primary aim and comparison of receptors with clinicopathological parameters: Age, histological type, grade of tumor and lymph node metastasis is also being focused in this study. Methods: All the patients of breast cancer with known hormone receptors status were included in the study from Nov.2018-Oct.2019. Results: Amongst 90 cases, 84.4% belong to invasive carcinoma of no special type (NST). The percentage of ER, PR and Her-2 Neu expression were 57.7%, 37.7%and 25.5% respectively. Mean age for HER-2Neu (+) and Her-2 Neu (-) were 53.4 and 52.04 respectively. Mean age for ER + and ER- were 56.42 and 47.56 respectively. Mean age for PR+ and PR- were 53.6 and 54.29 respectively. Patients with ER+, PR+ usually have lower grade1 tumor whereas patients with HER-2 Neu expression presented with higher grade tumor. There was an inverse relationship between ER, PR expression and HER-2 Neu expression (p-value<0.05). There was significant association between lymph node metastasis and Her-2 Neu and PR positivity. Conclusion: ER and PR expression were inversely related to Her-2 Neu receptor expression. Elder patients (age>45 years) have more ER and PR positivity than younger patients (age<45 years). Her-2 Neu expression is associated with higher tumor grade (Grade 2 and 3) and probability of metastasis to the axilla is more in cases with HER-2 Neu overexpression .