Published Paper Details:

ABSTRACT Background: Breast cancer is the most common cancer in women (24.2%) and the second most common cancer in the world (11.6%). Approximately 2.089 million new cases of breast cancer were identified in 2018. Expression of IGF-1R correlates with ER expression and predicts a favorable phenotype. Several studies have confirmed further cross-talk between ER and IGF-1R in breast cancer. Objective: The purpose of this study was to determine differences in IGF1R expression according to breast cancer subtypes in very young women at H. Adam Malik General Hospital Medan. Methods: This study was an observational analytic study using a cross-sectional design. The sample in this study was a woman with a diagnosis of breast cancer at a very young age at RSUP H. Adam Malik Medan from January 2015 to December 2019 who met the inclusion and exclusion criteria of 52 samples. Results: In this study, the median age of patients in luminal A breast cancer subtype was 33 years, where the age of the youngest patient was 23 years and the age of the oldest patient was 35 years. It was found that 33 patients (63.5%) had low IGF1R expression and 19 patients (36.5%) and 20 patients (38.5%) with an advanced local stage and only 1 patient (1.9%) with an early stage. In the test of significant differences in IGF1R expression according to breast cancer subtypes in very young women at H. Adam Malik General Hospital Medan with a p-value of 0.031 (p <0.05). Conclusion: There is a significant difference in IGF1R expression according to breast cancer subtype in very young women at RSUP H. Adam Malik Medan where higher expression was found in luminal A compared to luminal B and TNBC.