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Introduction: ADS is not a static condition, described in absolute terms, but a life-long illness. It is a phenomenon that depends on the interaction of biological, social, and cultural factors, e.g., religion and the symbolic value of alcohol in each culture, that determines how the person can relate to the substance in the individual and social process of learning how to consume alcohol. One of the phenomena in this learning process is the emergence of abstinence symptoms. When a person begins to drink alcohol to alleviate these symptoms, a strong correlation is formed to maintain both the development and persistence of dependency. Aim: To study adjuvant yoga therapy's effects on Quality of life (QOL) in patients undergoing alcohol de-addiction program at de-addiction clinic, department of Psychiatry, Mahatma Gandhi Medical College and Research Institute (MGMC&RI) in Pondicherry. Settings and design: 71 male patients undergoing an alcohol de-addiction program were recruited as subjects and randomly divided into Group A, who received Yoga therapy as per the CYTER protocol along with standard medication for daily sessions of 1.5 hours each, and daily counseling sessions for up to two weeks and Group B, who only received standard medical management. Methods and materials: Administration of World Health Organization (WHO) Quality of Life Bref version WHO 2004: WHOQOL Bref to all patients before and after the intervention. Statistical analysis used: JASP-0.9.2.0 software was used for Statistical analysis. Wilcoxon test was performed for intragroup comparisons, and the Mann-Whitney test was performed for intergroup comparison to arrive at the p values. Results: The scores in the intergroup comparisons were as follows: QOL- Physical health (p=0.0002), QOL- Psychological health (p=0.0053), QOL- Social relationship (p=0.2321), QOL- Environment (p=0.0212), QOL- Total Quality of life (p=0.0046). Whereas in the intragroup comparisons, the scores were as follows: QOL- Physical health (p<0.001), QOL- Psychological health (p<0.001), QOL- Social relationship (p<0.05), QOL- Environment (p<0.001), QOL- Total Quality of life (p<0.001). Conclusions: The present study supports previous studies on the benefits of Yoga and concludes that yoga therapy helps in spiritually improving the Quality of life of patients with Alcohol Dependence Syndrome (ADS).