Published Paper Details:

An adverse drug reaction is an unwanted, toxic effect of a drug that encountered at usual therapeutic dosages. The intensity of such reactions ranges from minor complications to serious life-threatening conditions or even death of the individual. Despite selective toxicity, antibacterial agents can produce harmful effects and contribute a large portion of drug-associated untoward reactions. Some antibacterials like chloramphenicol, aminoglycosides, tetracyclines, fluoroquinolones etc. exhibit different adverse reactions, especially in hepatic and renal diseases. Examples of adverse drug reactions include hypersensitivity reactions (penicillins), superinfections (tetracyclines) and direct tissue toxicity viz. aminoglycoside induced nephrotoxicity, tetracyclines induced hepatotoxicity, fluoroquinolones associated arthropathy, chloramphenicol associated bone marrow suppression and so on. The adverse reactions do not remain constant with all the patients but vary according to the genetic makeup of an individual. Similarly, drug interaction due to combination therapy further may increase the possibility and magnitude of adverse drug reactions. This review is an effort to bring forth commonly encountered adverse drug reactions and drug interactions associated with various antibacterial drugs in veterinary practice.