Published Paper Details:

The present research study was aimed to develop a floating tablets containing atenolol as a model drug by using natural polymer guar gum (GG) and hydroxyl propyl methyl cellulose (HPMC). The atenolol floating tablets were prepared by direct compression technique based on effervescent approach using sodium bicarbonate as a gas generating agent. The prepared tablets were evaluated for weight variation, hardness, friability, drug content, tablet density, floating lag time, total floating time and in vitro release studies. The effect of combination (1:1) of polymers GG and HPMC proportion on in vitro drug release profile was evaluated. The floating lag time and total floating time of all the formulations were increased by increasing polymers concentration. The formulations containing sodium bicarbonate 40 mg per tablet showed desired buoyancy. The in vitro studies revealed that, the atenolol release could be sustained upto 24 by increasing the proportion of GG and HPMC mixture. Further, the floating tablet containing 35% of mixture of HPMC (17.50%) and GG (17.50%) in the ratio 1:1 with an average tablet weight of 400mg released 98.23% at the end of 24 hours was found to be suitable for successfully sustaining the atenolol release upto 24h in physiological environment of stomach and to improve the patient compliance. The FTIR spectra confirms that there is no interaction between drug and tablet excipients.