Published Paper Details:

Measurement systems for early and reliable detection of degenerative diseases, like Alzheimer�s disease (AD), are extremely important in clinical diagnosis. Among these, biochemical assays represent a commonly used method to differentiate patients from healthy population thanks to the sensitive recognition of specific biomarkers in biological fluids. So on beat actual limitations of these techniques in term of cost, standardization, and sensitivity, this study aimed to grasp a low-cost sensitive portable point-of-care (PoC) testing system supported on screen-printed electrochemical sensors. The designed circuit was implemented during a electrical device board and interfaced to a wireless system supported IOT data transmission so on enhance the portability of the proposed solution. Preliminary results were obtained by using controlled concentrations of electrolytic solutions and calibrating the sensors for antibodies and for a documented protein (i.e., interleukin 8) quantified by anodic stripping voltammetry (ASV). Findings from ASV measurements showed a sensitivity of 38 �A/(ng/ml) with a tested range from 1.25 ng/ml, with a limit of detection of two ng/ml. Further investigation will includes the validation of this PoC device by testing the concentration of a particular p53 protein isoform, which was recently identified to early correlate to AD development.