Published Paper Details:

Nasal pathway achieved faster and greater level of drug absorption due to more surface area, the preventing of first pass metabolism and readily accessibility. Topiramate is a widely useful for the treatment of epilepsy. It is useful for various types of partial-onset and generalized-onset seizures, and is therefore considered a broad-spectrum agent. The aim of present research work was to increase the solubility of Topiramate by making its inclusion complex with ?-cyclodextrin (?-CD) complex and to develop its thermally triggered mucoadhesive in situ gel (TTISG) as to overcome first-pass effect and consequently enhance its bioavailability. Formulation optimized by using central composite model total 18 formulations were obtained. The optimized formulation (F15) with a gelation temperature 29�C, gelation time 13 Second and drug release up to 90% after 5 hrs. As compared to marketed formulation it enhanced the bioavailability and as per the need of time is need to go for the further preclinical study to get the better exposure for the current research.