Published Paper Details:

The objective of present study is to determine the toxic effect of arsenic and cadmium on albino rats blood parameters. Animals were exposed with low and high doses of sodium arsenite and cadmium chloride, along control. They were treated for 30 and 60 days separately, in two experimental sets. In each of the experimental sets, Group A was control, groups B exposed with low dose of CdCl2 (2.6mg/kg.b.wt.), group C with high dose of CdCl2 (5.2mg/kg.b.wt.), group D with low dose of sodium arsenite (4.3 mg/kg.b.wt.), group E with high dose of sodium arsenite (8.6 mg/kg.b.wt.), and group F with combined low dose of cadmium chloride and sodium arsenite (2.6mg/kg.b.wt + 4.3 mg/kg.b.wt). The findings of this study indicates that rats intoxicated with arsenic and cadmium chloride for 30 days showed decrease in TEC, TLC, Hb and PCV (P<0.05) values in all the treated groups and increase in MCV and ESR (P<0.05) values. Rats exposed for 60 days showed significant fall (P<0.05) in all these parameters except ESR. Group F with combined exposure of arsenic and cadmium showed significant fall in almost all parameters compared to other groups. Differential leucocyte count also fluctuated significantly.