Published Paper Details:

SARS-CoV-2 induced COVID-19 is continued to spread. In this present situation, where the virus has spread rapidly all over the world, and a meaningful treatment or vaccine is yet to be available, the biggest challenge arises on how to combat its spread. Human infection by SARS-CoV-2 results extremely heterogenous symptoms, ranging from asymptomatic or mild cases to severe hypoxia and acute respiratory distress syndrome (ARDS) depending upon host immune status. However, the exact mechanism of occurrence of an asymptomatic carrier of COVID-19 is not clearly understood. The major and yet to be resolved question is however, the role of �asymptomatic carrier� in spreading the disease. Herein, we summarize our current understanding on the possible clinical significance of asymptomatic COVID-19 infection. Particularly, the evolutionary significance, host antiviral response to SARS-CoV-2 infection and possible outcome in terms of asymptomatic carrier are briefly discussed. The resulting �asymptomatic carrier� may be the outcome of an efficient host antiviral defense, that effectively limits but could not block SARS-CoV-2 replication, and asymptomatic shedding might occur.