Published Paper Details:

Solid crystalline materials having more than two ionic or molecular compounds preferably in a stoichiometric ratio that are in single phase and not either simple salts or solvates are called as cocrystals. Cocrystalization is useful method as it can improve bioavailability of drug also improve physicochemical properties without affecting pharmacological activity of the drug. Formation of cocrystal was found to be pH dependent and coformer selection is one of very important aspect to be considered while forming Cocrystals of API. In the present Review properties of API that are modified by cocrystals has been discussed. Thereafter Coformer selection and methods used for preparation of cocrystas are described. The formation of cocrystals has been confirmed by various screening methods such as virtual cocrystal screening, thermal methods (DSC, TGA), Saturation stability testing etc. Cocrystls are evaluated for the stability, dissolution etc. by different methods. Cocrystal formation is an alternative approach in the betterment of bioavailability and solubility of poorly soluble API when it is neutral or weakly ionized. This approach offers improved melting point, tabletablity, solubility, stability, permeability and hence bioavailability and all Therese aspects are described in the present review. The Cocrystal approach is still not widely explored but in future it is expected to increase the industrial interest in pharmaceutical cocrystals Though there is inadequacy in marketed products and issues about safety and toxicity of coformers, we found heightened interest and activity in this specific area aiming for better understanding of cocrystal formation and methods of preparation.