Published Paper Details:

Wurster Technique for Coating of powders or particles can be performed using bottom-spray where the nozzle is spraying from the bottom or using rotary module with a nozzle spraying from the side or tangentially. The fluidization pattern in the Wurster process is very critical. The bottom-spray Wurster method is very popular in the pharmaceutical industry for active layering and for coating to modify or control drug release. It was used for development of various dosage forms of Multiple Unit Particulate Systems with better therapeutic efficacy. The Wurster process has number of variables. The batch size, spray liquid viscosity, concentration, spray assembly setting, air distributor plate, column height, and dew point, etc. are easy to establish. To fix dependent variables like air volume, atomization air pressure, spray rate, product temperature trials were performed. Finally by using Quality by design optimize the critical parameters in the process. Before scale-up, key variables and their effect on output should be identified during lab and pilot scale. This process is particularly suitable for a controlled release/ extended release and delayed/ enteric coating of active ingredients layered in the form of pellet. In the Wurster process, a complete sealing of the surface can be achieved.