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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
FORMULATION & DEVELOPMENT OF ITOPRIDE HYDROCHLORIDE MICROSPONGES FOR TREATMENT OF PEPTIC ULCER AND GERD
Authors
Sunil B. Rathod, Vaibhav R. Vaidya
Keywords
Microsponges, Itopride hydrochloride, Central Composite Design (CCD), Eudragit S-100, Quasi-emulsion solvent diffusion, Scanning Electron Microscopy (SEM), Extended release.
Abstract
Abstract: Itopride hydrochloride is a prokinetic agent having dual mode of action used in gastroesophageal reflux disease. The aim of this investigation to develop extended release microsponges of itopride hydrochloride using Eudragit S-100 polymer to extend the drug release over longer period of time to minimize dosing frequency and side effects. Itopride hydrochloride microsponges were prepared by quasi-emulsion solvent diffusion method. Optimization were performed by response surface methodology-central composite design. The evaluation of microsponges done by different parameter such as particle size, percentage entrapment efficiency, scanning electron microscopy. The drug release was found to depends upon the polymer concentration. Thus, concluded that prepared itopride hydrochloride microsponges will be more effective and reduce dosing frequency and side effects.
IJCRT's Publication Details
Unique Identification Number - IJCRT2008173
Paper ID - 197898
Page Number(s) - 1639-1648
Pubished in - Volume 8 | Issue 8 | August 2020
DOI (Digital Object Identifier) -
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Sunil B. Rathod, Vaibhav R. Vaidya, "FORMULATION & DEVELOPMENT OF ITOPRIDE HYDROCHLORIDE MICROSPONGES FOR TREATMENT OF PEPTIC ULCER AND GERD", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.8, Issue 8, pp.1639-1648, August 2020, Available at :http://www.ijcrt.org/papers/IJCRT2008173.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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