Published Paper Details:

The aim of this current work was to formulation and evaluation of alginate beads to increase the sustain release action of repaglinide over the floating drug delivery systems. Method: These repaglinide alginate beads were formulated by dripping technique for the multiple division of floating formulation by means of polymeric drug and gas-forming agent. Drug and polymers were subjected for compatibility studies using FTIR. The formulated beads were characterized for particle size, percentage drug entrapment efficiency, scanning electron microscopy, in-vitro buoyancy and in-vitro drug release. Results: Percentage drug entrapment was revealed the range between 59.643�.561 to 86.181�.521. And in-vitro drug release was demonstrated to be 53.997�0.297 to 72.819�0.195. From the in-vitro drug release, it was indicated the enhancing of the concentration of sodium alginate with the drug that resulted in advance delayed of the drug release. Conclusions: The obtained results from the experiment were exhibited the better sustained action of the selected drug for the floating drug delivery in the form of alginate beads. It was also best fitted in Higuchi model.