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ABSTRACT Stress is a common problem in modern society. It put its impact on people of every field. Stress affects all dimensions of an individual�s life in the form of physiological, psychological or emotional. Nursing has been spotted as a high-stress profession that is not just physically demanding but also emotionally and intellectually demanding, which can develop the various kind of stress. The main aim of the current study was to see the influence of self-esteem and social support on perceived occupational stress among nurses. 100 nurses participated in this study. Nurses filled questionnaires and also completed the family support scale. Rosenberg self-esteem scale and the stress management scale by Bhargawa were used. Results indicate that there is a remarkable interconnection among self-esteem, family support and occupational stress. The study revealed that positive self-esteem and family support minimizes the occupational stress & both are the functions as stress inhibitors.