Published Paper Details:

In the present study, there was an attempt to make fast dissolving tablets using the direct dissolution method containing Nifedipine-Manitol solid dispersion. The main objective of the work was to prepare Nifedipine solid dispersion with Manitol to initiate action. The solid dispersion was prepared by the solvent evaporation method and evaluated for cumulative drug release. FDT was formulated by direct compression method using different superdisintegrants such as, CCS and SSG in different range (1-3%). Preformulation studies were performed on the powder mixture for tablets. The flow properties (F1-F18) of the mixture were evaluated by the determining of Carr�s index, Hausner ratio and angle of repose. The formulated tablets were evaluated for thickness, hardness, friability, weight variation, wetting time, drug content uniformity, disintegration time and In-vitro dissolution studies. Thus it was concluded that FDT with Nifedipine-Manitol solid dispersion with reduced dissolution time can be prepared by direct compressing method, using co-processed mixture of Cross Carmellose Sodium and Sodium Starch Glycolate in the ratio1% and 2% prepares as superdisintegrants respectively.