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In the world of otorhinolaryngology chronic suppurative otitis media is one of the most commonly encountered diseases. The present prospective study was conducted at peripheral institute in North India towards clinico-microbiologic evaluation of chronic suppurative otitis media. Aerobic bacteria are mainly responsible for active csom so we had main focus on them in the present study. An attempt was made, to have a glimpse of the current antibiotic sensitivity pattern, with special reference to ciprofloxacin. Main aim of the present study is to see the types of aerobic bacteria involved in CSOM, in our region. In our study we collected aural swabs from 100 different ears, from 94 patients who had complaint of ear discharge, continuous or intermittent, with a non- intact tympanic membrane for 12 weeks or more. Swabs were sent to microbiology laboratory for culture and sensitivity tests. Bacteria could be isolated in 73 cases and 27 swabs were culture negative. The commonest bacteria isolated was Staphylococcus aureus (41),followed by E. coli (12), proteus (8) and klebseilla (2) pseudomonas(2).Twenty two patients had bilateral ear discharge of which 16 had staphylococcus aureus in both ears,three had proteus in both ear swabs, one grew proteus in one ear and no growth in the other, and one patient showed absolutely no aerobic bacteria in any of his ear swabs. Among the culture positive cases (n = 73) S. aureus in 41 cases. gram negative bacteria were isolated in (n = 32) cases. Among 100 patients number of male and female patients was 50 and 44, respectively. Pseudomonas, E. coli, Bacilli proteus and S. aureus were the predominant bacteria involved in CSOM. Out of the 73 positive isolates cipro- floxacin was sensitive against 55 isolates i.e.75.3%., intermediately sensitive in 14 and resistant in only 4 isolates. It is concluded in our study that, gram positive bacteria especially staphylococcus aureus is the commonest bacteria involved in CSOM in this part of north India. Ciprofloxacin is an important drug in the management of active CSOM as it is cheap, less ototoxic and widely available as topical preparations.