Published Paper Details:

Mechanical ventilation associated with delirium is the most commonly reported repercussion in intensive care unit patients, characterized by hypoxia, inflammatory storm and sometimes due to sedatives. The most common types of delirium in this cohort patients are hypoactive and mixed-type of delirium which develops in 2-24 hours from admission. Delirium is known to develop due to an imbalance in the synthesis, release, and inactivation of some neurotransmitters, specifically by acetylcholine deficiency and dopamine activation. Delirium usually presents as a group of symptoms with an acute onset and a fluctuating course which have been categorized into cognitive and behavioral groups. This is a prospective observational cohort study conducted at Gleneagles Aware Global Hospitals, L.B Nagar, Hyderabad. for a study period of six months. 200 patients admitted with the hospitalization history of more than 24 hours in critical care units were enrolled as study population. Patient data collection form, contains the socio-demographic details of the patients and Observational study Informed Consent form was prepared for patients understanding for agreeing to participate in the study. In this study, out of the 200 study population 133 patients were not ventilated during the course of therapy in the ICU based on current disease state (66.5%) in which 25 developed mild, 22 developed moderate, 14 developed severe type of delirium and 72 were assessed to be non-delirious. Out of 67 ventilated patients based on current therapy in the ICU (33.5%), 8 developed mild, 13 developed moderate, 41 developed severe type of delirium and 5 were assessed to be non-delirious and from the P-value <0.0001, there is significant correlation between mechanical ventilation due to current disease status and development of delirium in ICU. Mechanically ventilated patients were assessed (92.5%) to be at greater risk of developing delirium compared to that are not ventilated. Ventilation is clinically significant (P-value <0.0001) when correlated to delirium, indicating ICU patients are at risk of developing delirium which is temporary within the ICU during the course of hospitalization (resolves with relevant patient orientated management).