Published Paper Details:

Nanoparticles are very attractive concern for scientists in recent years. Their different physical and chemical properties make them a very good vehicle for drug molecules for that reason their application in therapeutics and drug delivery research is remarkable. Many metals are already being used to formulate nanoparticles for this purpose. The flavonoids have also grabbed attention of many research groups for their tremendous efficiency for combating a huge variety of diseases. Hence, Metal nanoparticle drug composite formulation is one of the prime concerns in today�s research. To understand the attachment of drug on nanoparticle, it is very much important to study the interaction between drug and the nanoparticle. That is why; here we are reporting the interaction between two flavonoids (Gallic acid and Ellagic acid) with eight metal atoms (gold, silver, iron, copper, nickel, zinc, platinum and palladium). We used Avogadro software to formulate the nanocomposite model structures and to minimize the energy level. From the results it can be concluded that the �OH groups present at the meta positions of Gallic acid are most suitable site for binding of metal atom and in case of Ellagic acid the binding site would be the -OH groups present at 2 and 7 positions. For both Gallic acid and Ellagic acid, platinum was found to be most suitable nanocomposite having lowest energy level.