Published Paper Details:

Pellets are the multiparticulate drug delivery system which prove to be promising and highly flexible system with various kinetics of drug release such as immediate release, sustained and controlled release which are easy to formulate. In order to overcome the physicochemical interaction such as drug-excipient or drug-drug interactions multiparticulate dosage forms can be implemented. The technology of pelletization as oral drug delivery system are gaining substantial attention in the present time. Pelletization is the process where the aggregates of granules or fine powders mixture of drugs and excipients. They form small spherical or semi-spherical free flowing solid units ranging from 0.5 mm to 1.5 mm. Pellets are commonly used as multiparticulate systems as it has technical as well as clinical advantages over single unit dosage forms. The present review focuses on advantages, disadvantages, mechanism of pellet formation, different methods of pellet preparation, characterization of pellets, and also the recent approaches for pelletization techniques.