Published Paper Details:

Increasing research interest has been focused on controlled drug delivery using natural and biocompatible polymers as drug carriers in recent years. In the present study transdermal patch of Vildagliptin was developed using Aloe Vera gel powder as a polymer and Almond oil as penetration enhancer. Patches were prepared by solvent evaporation technique. Optimization was carried out by response surface methodology using central composite design with polymer concentration(X1), plasticizer concentration(X2), and concentration of permeation enhancer(X3) as independent variables. Hydrophilic nature of polymer as well as plasticizer and Interaction with intercellular protein to disrupt the structure of stratum corneum were responsible for increase in drug release with increase in their concentrations. Optimized formulation F9 exhibited high drug release, folding endurance Thus, It can be concluded that transdermal patch of Vildagliptin using aloe vera gel powder will be more efficacious and gives synergistic effect to drug