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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
INSILICO COMPARATIVE ANALYSIS OF INTER AND INTRA GENERIC DIVERSITY OF PBPA ENCODED BY MECA GENE OF STAPHYLOCOCCUS AUREUS AND THEIR ANNOTATIONS
Authors
Rekha Patil, Shrikanth R K, Mohan Reddy K., G. R. Naik
Keywords
mecA gene, comparative analysis, resistance, pBLAST, PSI BLAST and Protein Phylogeny.
Abstract
Methicillin resistant Staphylococcus aureus (MRSA) is an utmost concern by many researchers. MecA gene codes for the class of penicillin binding proteins (PBP) which are responsible for antibiotic methicillin resistance. It is a genetic cassette of 52 kb with two recombinase genes. In the present study, Penicillin binding protein sequences of ten intra generic Staphylococci were compared with five selected pathogens of other genera. pBLAST with PSI (Position Specific Iterated) algorithm was used to compare and analyse penicillin binding protein sequences from existing protein sequence databases. The percentage of identity with total query coverage and the relatedness were studied by constructing a dendrogram using MEGA 0.6 software. Further, the functional and structural annotations of ten intra and inter generic PBPs were compiled from Pfam and Uniprot databases for understanding the functional and structural domains.
IJCRT's Publication Details
Unique Identification Number - IJCRT1807137
Paper ID - 187375
Page Number(s) - 145-155
Pubished in - Volume 6 | Issue 2 | April 2018
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Rekha Patil, Shrikanth R K, Mohan Reddy K., G. R. Naik, "INSILICO COMPARATIVE ANALYSIS OF INTER AND INTRA GENERIC DIVERSITY OF PBPA ENCODED BY MECA GENE OF STAPHYLOCOCCUS AUREUS AND THEIR ANNOTATIONS", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.6, Issue 2, pp.145-155, April 2018, Available at :http://www.ijcrt.org/papers/IJCRT1807137.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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