Published Paper Details:

Microdetermination of the trithiocarbonate derivative of the drug captopril as its Os (VIII) complex is achieved spectrophotornetrically. ? max 610 am Beer's law range 6.33X10-8 mg to 6.96X10-7 mg ? =3.74X103 L Mol-1cm-1 metal ligand ratio was confirmed by Job's method and was found to be 1:1. Interference of foreign metal ions was also studied, one ppm of captopril trithiocarbonate could sustain 0.00031 ppm of rathenium trichloride, 0,00022 ppm of nickel sulphate, 0.0003 ppm of zinc sulphate 0.0052 ppm of cobalt nitrate, 0.0002 ppm of copper acetate, palladium chloride, ferric chloride and ferrous ammonium sulfate interfere severely. Characterization of the complex was done by elemental analysis (CHN) which confirms the ascertain the ratio as FTIR spectrum of the complex ascertain the bindinz, of sulphur atom of trithiocarbonate group, oxygen molecules. No ESR signals is indicative of diamagnetic nature of the complex and covalent nature of the complex. The proton NMR spectrum of the complex further confirms the involvement of sulphur oxygen atoms of trithiocarbonate and carbonyl group respectively with Os(VIII), The TGA of the complex confirm the proposed structure and presence of coordinated and lattice water molecules.