Published Paper Details:

The present paper describes how calcium homeostasis is related with electrostrictive energy linked with pH homeostasis. The proposed model incorporates electrostrictive energy as input and bone calcium level as output. The model is also comprised of pH homeostasis, antiporter homeostasis, PTH homeostasis and calcium homeostasis. Electrostrictive energy in E. Coli plays very crucial role for homeostasis of bone calcium. As we know that bone calcium plays very important roles, which are linked with fundamental biological processes involving muscle contraction including the cardiac muscles, which can prevent myocardial infarction during heart attack. Tight regulation of the extracellular fluid (ECF) calcium concentration is maintained through the action of calcium sensitive cells. The precise control of calcium ion in extracellular fluids is of great importance for maintaining the health of individuals. The calcium homeostasis is linked with parathyroid hormone and VDR depending on the level of calcium in ECF and formation of osteoblast cells. Also the homeostasis of intracellular calcium ([Ca++]i) and pH (pHi) is important in the cell’s ability to respond to growth factors, to initiate differentiation and proliferation, and to maintain normal metabolic pathways. This model has been simulated by using MATLAB 6.5 in order to facilitate comprehensive understanding of complex electrostrictive energy phenomena concomitant with capacitance relaxation phenomena associated with cancer. It has been revealed from the model that, more is the change of electrostrictive energy more will be the reduction of formation of osteoblast cells and decreased production of bone calcium. Electrostrictive energy linked with pH homeostasis affects the formation of osteoblast cells. The osteoblast cell lineage is responsible for bone development, growth, and remodeling. Variety of hormones and growth factors regulates the development of rapidly dividing osteoprogenitor cells into highly differentiated bone-forming osteoblasts . Activation of E Coli. due to electrostrictive energy reduces formation of osteoblast cells which will affect calcium homeostasis.