Published Paper Details:

The pH gradient in normal cells is tightly in tumor progression with regard to ion flux, the controlled by the activity of various pH-regulatoryregulation of its activity on a molecular level is membrane proteins including the isoform proteinonly recently becoming evident. The membrane of the Naþ/Hþ exchanger (NHE1). NHE1 isdomain of NHE1 is sufficient for ion exchange. constitutively active in a neoplasticHowever, its activity is regulated through the microenvironment, dysregulating pH homeostasisphosphorylation of key amino acids in the and altering the survival, differentiation, andcytosolic domain as well as by its interaction with proliferation of cancer cells, thereby causing themother intracellular proteins and lipids. Here, we to become tumorigenic. Cytoplasmic alkalinizationreview the importance of these regulatory sites and in breast cancer cells occurs as a result of what role they may play in the disrupted increased NHE1 activity and, while much isfunctionality of NHE1 in breast cancer metastasis. known about the pathophysiologic role of NHE1