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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 12 | Issue 5 | Month- May 2024
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Paper Title
SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF N-SUBSTITUTED IMIDAZOLEDERIVATIVES FOR ANTIMICROBIAL ACTIVITY
Authors
Anila Mishra, Rakhi Mishra
Keywords
1H-NMR, FT-IR, imidazole, minimum inhibitory concentration, tube dilution method
Abstract
A series of N-substituted imidazole derivatives was synthesized. Imidazole nucleus was reacted with ethylchloroacetate to form imidazole ester. Reaction of the imidazole ester (I) with different amines yields the desired products (1a- 1e). The compounds were characterized by FT-IR, 1H-NMR and mass spectra. The synthesized compounds were evaluated for the antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger by determination of MIC (minimum inhibitory concentration) using tube dilution method. Compound (1b) was found to be the most active antimicrobial compound amongst others in the series.
IJCRT's Publication Details
Unique Identification Number - IJCRT1134747
Paper ID - 227552
Page Number(s) - 216-221
Pubished in - Volume 4 | Issue 3 | August 2016
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Anila Mishra, Rakhi Mishra, "SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF N-SUBSTITUTED IMIDAZOLEDERIVATIVES FOR ANTIMICROBIAL ACTIVITY", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.4, Issue 3, pp.216-221, August 2016, Available at :http://www.ijcrt.org/papers/IJCRT1134747.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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