Published Paper Details:

In present study tablets were prepared with three different techniques like direct compression, dry granulation and wet granulation and were evaluated for drug release. The drug release profile was compared with marketed product. Saturation solubility studies were performed for dissolution media selection. Tables with direct compression showed compression issues due to poor flow nature of blend. Tablets prepared with dry granulation showed slight improvement in the drug release. Tablets prepared with wet granulation process showed significant improvement in drug release when compare with marketed product. Full factorial design of experiments was conducted to find out effect of significant factors influencing the drug release.Sodium starch glycolate and Hydroxypropyl cellulose were found to significantly increase the drug release profile. Diagnostic plots were performed and were found to be satisfactory. The characteristic 2Theta peaks of Ambrisentan API were observed at 8.898 (94.16% Relative Intensity) and 12.320 (100 % Relative Intensity), while in formulation the characteristic 2Theta peaks of Ambrisentan were observed at 8.971 (2.90 % Relative Intensity) and 12.376 ( 3.35 % Relative Intensity). This indicates that the cystallinity of drug is decreased in formulation due to the formation of solid dispersion.