Published Paper Details:

Abstract: Background: Chlorophytum borivilianum Sant. & Fern. (Liliaceae) has therapeutic application in Ayurvedic system of medicine. Roots of Chlorophytum borivilianum traditionally used for treatment of inflammatory disorders. The saponins is one of the major and important constituent present in these roots. Several studies have found evidence to support the belief that saponins have potent anti-inflammatory and analgesic properties. Aim: The aim of the present study was to evaluate anti-inflammatory, antiarthritic and analgesic activity of the fractions of saponin from isolated from roots of C.borivilianum. Material and Methods: The ethanol fraction of isolated saponins of C. borivilianum (EFS) at dose 3, 10 and 30 mg/kg p.o was evaluated in laboratory animals using carrageenan-induced paw edema, histamine-induced paw edema, cotton pellet induced granuloma, Freund's adjuvant-induced arthritis, Eddy's Hot plate method, tail flick method. Effect of EFS 30 mg/kg,on bone deformation was evaluated by X-ray radiography. Result: The results showed that the EFS produced significant inhibition in carrageenan-induced inflammation, histamine-induced inflammation, cotton pellet induced granuloma and Freund's adjuvant induced arthritis in rats. The maximum effect observed at 10 and 30 mg/kg p.o. It also increases reaction time significantly indicating analgesic activity. Conclusion: EFS at 10 and 30 mg/kg possess anti-inflammatory and anti- arthritic activity produced by inhibition of prostaglandin, inhibition of granuloma formation with mild central analgesic activity.