Volume 12 | Issue 3 |

 Abstract

Topical drug delivery system is a painless route of drug administration. There are different skin diseases and infections caused by fungus and microorganisms. which are treated with the probiotics or living microorganism which are used as active pharmaceutical agent. The purpose of writing this review article was to compile the recent literature with a special focus on a rational approaches of topical probiotic gel formulation and basic components of topical drug delivery systems. Topical applications of drugs have advantages of delivering the drug directly at the site of action and acting for a prolong period of time. Skin is one of the most widespread and important accessible organs on the human body for topical incorporation. it is the main route of topical drug delivery system. Many widely used topical probiotic products like ointments, creams and lotions have number of disadvantages as they are usually very sticky causing un-comfort to the patient after application. Moreover, they also have less spreading coefficient and need to apply with rubbing and also have the problem of stability , due to all these factors, within the major group of semisolid preparations; the use of gels has increased both in cosmetics and in pharmaceutical preparations because, A probiotic gel is colloid and it is typically 99% by weight formed by liquid material, which is immobilized by surface tension between it and a macromolecular network of fibers built from a small amount of a gelatinous ingredient present in the formation. In this revive we discus about the general Prepration and evaluation of probiotic gel

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 Keywords

Skin, Probiotic, gel, Topical, Novel

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The nation's economic growth is significantly influenced by the gross domestic savings. A high rate of domestic saving could result in more rapid economic growth. This study aims to examine the trend and major determinants of gross domestic savings rate in India using secondary annual data for the period 2010-2022. Data is collected from the website of World Bank. The macroeconomic variables used include foreign direct investment, inflation and GDP. The study adopts Augmented Dickey-Fuller unit root test and ordinary least square regression test to examine the long run relationship between the variables under study.

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Gross Domestic Savings, GDP, Inflation, FDI, India.

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Along with focusing on Kosovo, the paper looks at the parts of regional growth and stresses how the economy, society, and environment are all connected. It says that long-term economic infrastructure and fair growth are important for a region's success. This article takes a critical look at the link between political leadership and growth, focused on what happened in African states after they got their independence. The piece goes into detail about the different ideologies, development models, and problems that leaders during the Cold War had to deal with as they tried to decide what would happen to their countries. Plan in mind: modernization The piece goes into theory and shows how it can help us understand the shift from premodern to modern states. The main idea of the thesis is that good governance is important for growth and that political leadership has an impact on economic strategy. This book uses Ghana and other countries as examples to look at leadership, political governance, and economic growth in different ways. The piece talks about how different types of leadership, government structures, and economic policies can affect development outcomes. It stresses how important it is to have strong institutions and a government that includes everyone. The book looks at party and national leadership and includes a case study of Kenyan politics. The book is about Kenya's political history. It focuses on how power has grown and how different leaders have shaped development plans and outcomes. Lastly, a Case Study of Kenya is given to show the good and bad points of Kenya's growth path. This includes how parastatal institutions work, the results of constitutional changes, and what happens when there is only one party in the parliament.

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 Keywords

Leadership, Economy, Governance, Modernisation, Development

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Nowadays it is very important to have a proper road network for the purpose of good transportation. For Few places road network is not available while the traffic is higher and enough. Pavement is generally being constructed and used for the purpose of smooth and comfort moment of the traffic. Flexible pavements will be subjected to load by wheel develop stress particles-to-particles transmit to the lower grades of layers through the granular structure. The pavement is subjected to the wheel loading action on it and the load is to be distributed to a larger area, such that the decrease in stress will occur with respect to the depth. The patch considered in this project is of Kodad to Khammam Road, Telangana. The current condition of the Kodad to Khammam Road is very much disturbed with the presence of uneven undulations as heavy loaded vehicles like moment of trucks took part. Hence, for the purpose of the fulfilment of all the above requirement factors and for the comfort moment of traffic adopted the effective design of flexible pavement. In this paper, we are enclosing the design report Kodad to Khammam Road which includes all the which comes under the project of the pavement construction.

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Design, Flexible Pavement

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This manuscript is highly suitable for publication in the journal given its alignment with the journal's aim, mission, and scope. The work addresses a critical issue in healthcare scheduling, leveraging innovative sensor technology to enhance patient care and optimize resource utilization. By streamlining the appointment booking process, the manuscript contributes significantly to the journal's mission of advancing healthcare efficiency and patient satisfaction. The novelty lies in the integration of sensor data with scheduling algorithms, offering a unique approach to improving healthcare delivery. Furthermore, the manuscript's emphasis on real-world application and tangible benefits for both patients and healthcare providers underscores its relevance and importance within the journal's domain.

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 Keywords

Doctor Scheduling, Patient Care, AI Algorithms, Sensor Integration, Healthcare Efficiency, Resource Optimization, Appointment Management, Patient Satisfaction

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Children in India rely on family, joint family, caste, and community for support. However, weakening social structures mean outside agencies must step in when families can't provide care. Mental retardation, not a disease but a condition of delayed mental development, affects both physical and mental abilities. It slows learning, reduces understanding, and impacts speech, language, hearing, vision, and coordination. The American Association of Mental Retardation (AAMR, 1992) defines it as below-average intellectual functioning with deficits in adaptive behavior, evident from childhood. Addressing mental retardation requires holistic support to improve overall functioning and quality of life. The aim of the study is to assess the performance skills of mentally retarded children. The study was conducted with the children (30) those who were received more than 2 years training. Boys made up 70% of the sample, indicating more boys in these institutions possibly because parents were reluctant to send their daughters. The health status of other family members of mentally retarded children was examined, on paternal side 94% were found to be normal and 6% were found to be mentally retarded and on maternal side 86% were found to be normal and 14% were found to be mentally retarded. Mentally retarded children often struggle with cognitive skills, affecting their reading. The study concludes that teachers need to concentrate more on the moderately retarded children and need to introduce new parent training programs with appropriate schedule through implementation of effective mass media approach.

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Children, Mental Retardation, Intellectual ability, Behavioural Assessment, Performance Skill

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An inflammatory, autoimmune skin condition known as psoriasis can have a wide range of symptoms. Atypical keratinocyte proliferation, neutrophil activation, and T-cell (T-lymphocyte) activation are among it is principal characteristics. The growth and multiplication of keratinocytes are hindered by a range of cytokines released by T and dendritic cells. One way to treat psoriasis is with a variety of methods, such as phototherapy, systemic, and topical techniques, but there isn't a 100% cure for the condition. The anti-psoriatic drugs of today are costly, prone to negative side effects, and frequently cause the illness to recur. This review article discusses studies on natural herbs used as anti-psoriasis agents. Its objective is to offer fresh approaches to treating psoriasis. The outcomes showed that the anti-psoriatic effect of the herbal mixture was caused by various constituents. Scholars worldwide are searching for novel, safe, and efficacious psoriasis medications derived from natural resources, as the synthetic drugs currently prescribed for the condition have a connection to several unfavorable side effects.

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Psoriasis, Topical treatment, Medicinal Plant, Skin, Keratinocytes.

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Online marketplaces have emerged as dominant platforms in the retail landscape, revolutionizing the way consumers shop and businesses operate. This article explores the multifaceted nature of online marketplaces, highlighting their convenience, selection, and accessibility for consumers, while also addressing the challenges and concerns they pose in terms of counterfeit products, privacy, and market dominance. The discussion delves into the opportunities online marketplaces present for businesses of all sizes, leveling the playing field and democratizing access to the global marketplace. Also, the article examines the role of regulation and policy in addressing issues within the digital economy, such as consumer protection, data privacy, and competition. Looking towards the future, the article discusses emerging trends and innovations shaping the landscape of online marketplaces, including augmented reality shopping experiences, block chain-based supply chain solutions, and AI-driven personalization. This article provides a comprehensive overview of the evolution, impact, and prospects of online marketplaces, emphasizing the importance of adaptation, innovation, and collaboration in navigating the complexities of the digital marketplace

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Online Marketplaces, E-commerce, Digital Shopping Landscape

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The project aims to improve the safety and appropriateness of video content for young children by using an automated content analysis system specifically designed for YouTube. It works by comparing a variety of video elements - such as text content, visual sceneries, frame sequences, audio qualities, and color usage - to predetermined standards. Rapid frame changes, unsettling noises, excessive use of vivid colors, improper language or conversation, and disagreeable graphic components are just a few examples of the potentially hazardous or inappropriate information that the system effectively recognises and filters out. The last Filtering Module evaluates all of the analyzer outputs together, allowing for a thorough decision - making process to establish video appropriateness. This technology plays a vital part in ensuring a secure online environment for young viewers by utilizing a comprehensive approach and advanced content analysis tools, giving parents and guardians greater trust in their children's online video experiences.

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 Keywords

Video content analysis, YouTube safety, Automated filtering, Child-appropriate content, Parental trust.

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Nishakatakadi kashaya churna is a herbal formulation. Ingredients used in the drug are Haridra, Kataka, Pranati mula, Lodhra, Amalaki, Bhadarika, Meharimula, and Usira. The Ingredients in Nishakatakadi Kashaya and Nishamlaki Kashaya are having majorly Laghu, Tikshna guna, Katu rasa and Ushna Veerya and are Kapha-Vata shamaka. They act as Mootrala and has Rasayana Property1. Preliminary Physio Phytochemical studies was done using standard procedure with aqueous, chloroform, ethanol, methanol and acetone extracts of Nishakatakadi kashya churna. The ingredients of the drug has vata-kaphashamaka, dahahara, Rasayana property along with anti-diabetic effect which are mainly needed for treating Madhumeha. The inference from this study can be used as reference standard in further quality control researches.

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 Keywords

Physio chemical analysis, Madhumeha, Nishakatakadi kashaya churna, diabetes mellitus

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