ISSN2320-2882
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Paper Title
DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW
Authors
Vishakha Sunil Kharwade , Dr. Deepti Pandey , Dr. Sonal Dhabekar
Keywords
Neurocosmeceuticals; Skin-brain axis; Psychodermatology; HPA axis; Neurotransmitters.
Abstract
The field of neurocosmeceuticals has emerged as an innovative advancement in cosmetic science, integrating concepts from neuroscience, dermatology, and pharmacology to target the skin-brain axis. This review explores the formulation and functional mechanisms of neurocosmeceuticals designed to regulate the bidirectional communication between the central nervous system and the skin through neuroendocrine and immune pathways. The skin functions as a neuro-immuno-endocrine organ that responds to psychological stress via activation of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in increased cortisol production, oxidative stress, inflammation, and impairment of the skin barrier. These changes are associated with various dermatological conditions such as acne, psoriasis, atopic dermatitis, and premature aging.Neurocosmeceuticals incorporate bioactive agents including peptides, adaptogens, antioxidants, and plant extracts to modulate neurotransmitter activity, reduce neurogenic inflammation, and restore skin homeostasis. The application of advanced drug delivery systems, such as liposomes, nanoparticles, and microemulsions, enhances the stability, penetration, and targeted delivery of active ingredients.Despite their promising potential, challenges remain, including insufficient clinical validation, lack of standardized evaluation methods, formulation instability, and regulatory uncertainties. Future developments emphasizing personalized skincare and technological advancements are expected to expand the scope of neurocosmeceuticals. Overall, these formulations represent a novel and holistic approach for managing stress-related skin disorders by addressing both physiological and psychological factors influencing skin health.
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IJCRT — journal style
"DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.14, Issue 4, page no.l913-l926, April 2026, Available :https://ijcrt.org/papers/IJCRT26A4387.pdf
APA — 7th edition
Kharwade, V. S., Pandey, D., & Dhabekar, S. (2026). DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW. International Journal of Creative Research Thoughts, 14(4), l913-l926. https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A4387
MLA — 9th edition
Kharwade, Vishakha Sunil, et al. "DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW." International Journal of Creative Research Thoughts, vol. 14, no. 4, 2026, pp. l913-l926, https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A4387.
Chicago — 17th, bibliography
Kharwade, Vishakha Sunil, Deepti Pandey, and Sonal Dhabekar. "DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW." International Journal of Creative Research Thoughts 14, no. 4 (2026): l913-l926. https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A4387.
Harvard — author–date
Kharwade, V.S., Pandey, D. and Dhabekar, S. (2026) 'DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW', International Journal of Creative Research Thoughts, 14(4), pp. l913-l926. Available at: https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A4387
IEEE — numbered reference
V. S. Kharwade, D. Pandey and S. Dhabekar, "DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW," IJCRT, vol. 14, no. 4, pp. l913-l926, Apr. 2026.
Vancouver — biomedical
Kharwade VS, Pandey D, Dhabekar S. DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW. IJCRT. 2026 Apr;14(4):l913-l926.
AMA — 11th edition
Kharwade VS, Pandey D, Dhabekar S. DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW. IJCRT. 2026;14(4):l913-l926. Accessed at https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A4387
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT26A4387,
author = {Vishakha Sunil Kharwade and Deepti Pandey and Sonal Dhabekar},
title = {DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW},
journal = {International Journal of Creative Research Thoughts},
volume = {14},
number = {4},
pages = {l913-l926},
year = {2026},
month = {April},
issn = {2320-2882},
url = {https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A4387}
}
RIS — EndNote, RefWorks
TY - JOUR
AU - Kharwade, Vishakha Sunil
AU - Pandey, Deepti
AU - Dhabekar, Sonal
TI - DEVELOPMENT OF NEUROCOSMECEUTICAL FORMULATION TARGETING THE SKIN-BRAIN AXIS: A REVIEW
T2 - International Journal of Creative Research Thoughts
JA - IJCRT
VL - 14
IS - 4
PY - 2026
SN - 2320-2882
UR - https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A4387
SP - l913-l926
ER -
Issue
Volume 14 Issue 4,
April-2026
Pages : l913-l926
Article Information
- Pages
- l913-l926
- Published
- April 2026
- Registration ID
- IJCRT_306398
- Published Paper ID
- IJCRT26A4387
- Research Area
- Science All
- Author Type
- Indian Author
- Location
- Wani, Maharashtra, India
- Peer Review
- Request Peer Review Report
- Licence
- CC BY 4.0 · Open Access
- ISSN & Impact Factor
- 2320-2882 · IF 9.17
- Downloads
- 147
- Permanent Link
- https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A4387
- Published Paper PDF
- https://ijcrt.org/papers/IJCRT26A4387.pdf
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