ISSN2320-2882
Impact Factor9.17
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CrossRefDOI
ESTD2013
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Paper Title
Gut Microbiota in Drug Metabolism and Personalized Medicine
Authors
Mahendra Diagambar Chaudhari , Ram Keshav sawarkar , Vaibhav Ramdas Ghanot , Aman Udaykumar Ingle , Raghunandan Ananta More
Keywords
Gut microbiota, Drug metabolism, Personalized medicine, Pharmacokinetics, Pharmacodynamics, Microbiome, Xenobiotics, Precision medicine, Microbial enzymes, Host-microbe interaction
Abstract
The human gut microbiota has emerged as a critical determinant in drug metabolism, influencing both pharmacokinetics and pharmacodynamics. Comprising trillions of microorganisms, the gut microbiome plays a significant role in the biotransformation of various xenobiotics, including therapeutic drugs. These microbial communities possess diverse enzymatic capabilities that can activate, inactivate, or toxify pharmaceutical compounds, thereby affecting drug efficacy and safety. Interindividual variability in gut microbiota composition has been identified as a key factor contributing to differences in drug response, leading to challenges in standard therapeutic regimens. Recent advances in metagenomics, metabolomics, and systems biology have facilitated a deeper understanding of host-microbiome interactions, paving the way for microbiome-based personalized medicine. This review highlights the mechanisms by which gut microbiota influences drug metabolism, discusses clinically relevant drug-microbiome interactions, and explores the potential of microbiota profiling in optimizing individualized therapeutic strategies. Furthermore, current challenges and future perspectives in integrating gut microbiome data into precision medicine are critically evaluated.
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IJCRT — journal style
"Gut Microbiota in Drug Metabolism and Personalized Medicine", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.14, Issue 3, page no.j177-j189, March 2026, Available :https://ijcrt.org/papers/IJCRT26A3106.pdf
APA — 7th edition
Chaudhari, M. D., sawarkar, R. K., Ghanot, V. R., Ingle, A. U., & More, R. A. (2026). Gut Microbiota in Drug Metabolism and Personalized Medicine. International Journal of Creative Research Thoughts, 14(3), j177-j189. https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A3106
MLA — 9th edition
Chaudhari, Mahendra Diagambar, et al. "Gut Microbiota in Drug Metabolism and Personalized Medicine." International Journal of Creative Research Thoughts, vol. 14, no. 3, 2026, pp. j177-j189, https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A3106.
Chicago — 17th, bibliography
Chaudhari, Mahendra Diagambar, et al. "Gut Microbiota in Drug Metabolism and Personalized Medicine." International Journal of Creative Research Thoughts 14, no. 3 (2026): j177-j189. https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A3106.
Harvard — author–date
Chaudhari, M.D. et al. (2026) 'Gut Microbiota in Drug Metabolism and Personalized Medicine', International Journal of Creative Research Thoughts, 14(3), pp. j177-j189. Available at: https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A3106
IEEE — numbered reference
M. D. Chaudhari, R. K. sawarkar, V. R. Ghanot, A. U. Ingle and R. A. More, "Gut Microbiota in Drug Metabolism and Personalized Medicine," IJCRT, vol. 14, no. 3, pp. j177-j189, Mar. 2026.
Vancouver — biomedical
Chaudhari MD, sawarkar RK, Ghanot VR, Ingle AU, More RA. Gut Microbiota in Drug Metabolism and Personalized Medicine. IJCRT. 2026 Mar;14(3):j177-j189.
AMA — 11th edition
Chaudhari MD, sawarkar RK, Ghanot VR, Ingle AU, More RA. Gut Microbiota in Drug Metabolism and Personalized Medicine. IJCRT. 2026;14(3):j177-j189. Accessed at https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A3106
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT26A3106,
author = {Mahendra Diagambar Chaudhari and Ram Keshav sawarkar and Vaibhav Ramdas Ghanot and Aman Udaykumar Ingle and Raghunandan Ananta More},
title = {Gut Microbiota in Drug Metabolism and Personalized Medicine},
journal = {International Journal of Creative Research Thoughts},
volume = {14},
number = {3},
pages = {j177-j189},
year = {2026},
month = {March},
issn = {2320-2882},
url = {https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A3106}
}
RIS — EndNote, RefWorks
TY - JOUR
AU - Chaudhari, Mahendra Diagambar
AU - sawarkar, Ram Keshav
AU - Ghanot, Vaibhav Ramdas
AU - Ingle, Aman Udaykumar
AU - More, Raghunandan Ananta
TI - Gut Microbiota in Drug Metabolism and Personalized Medicine
T2 - International Journal of Creative Research Thoughts
JA - IJCRT
VL - 14
IS - 3
PY - 2026
SN - 2320-2882
UR - https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A3106
SP - j177-j189
ER -
Issue
Volume 14 Issue 3,
March-2026
Pages : j177-j189
Article Information
- Pages
- j177-j189
- Published
- March 2026
- Registration ID
- IJCRT_304541
- Published Paper ID
- IJCRT26A3106
- Research Area
- Pharmacy All
- Author Type
- Indian Author
- Location
- Buldhana, Maharashtra, India
- Peer Review
- Request Peer Review Report
- Licence
- CC BY 4.0 · Open Access
- ISSN & Impact Factor
- 2320-2882 · IF 9.17
- Downloads
- 167
- Permanent Link
- https://ijcrt.org/viewpaperforall.php?paper=IJCRT26A3106
- Published Paper PDF
- https://ijcrt.org/papers/IJCRT26A3106.pdf
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International Journal of Creative Research Thoughts
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