ISSN2320-2882
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Paper Title

CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS

Authors

Anku Kumar Giri , Rachna Bist , Dr. Praveen Kumar

Keywords

Type 2 Diabetes Mellitus, Monotherapy, Combination Therapy, Glycemic Control, HbA1c, Antidiabetic Drugs, Insulin Resistance, Pharmacotherapy

Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic ?-cell dysfunction. Effective glycemic control is critical to prevent microvascular and macrovascular complications associated with T2DM. This study aimed to evaluate the comparative efficacy and safety of monotherapy versus combination therapy in managing T2DM. A total of 100 patients were enrolled, with 50 receiving monotherapy and 50 receiving multi-drug therapy. Clinical outcomes, including fasting plasma glucose, postprandial glucose, and HbA1c levels, were monitored over six months. Results demonstrated that combination therapy produced a significantly greater reduction in HbA1c (1.8%) compared to monotherapy (0.9%), with manageable adverse effects. The findings suggest that combination therapy offers superior glycemic control by targeting multiple pathophysiological mechanisms of T2DM, while monotherapy remains effective during early disease stages. Personalized treatment strategies are recommended to optimize long-term outcomes in diabetic patients.

How To Cite

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IJCRT — journal style
"CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.14, Issue 9, page no.b246-b253, September 2026, Available :https://ijcrt.org/papers/IJCRT2609130.pdf
APA — 7th edition
Giri, A. K., Bist, R., & Kumar, P. (2026). CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS. International Journal of Creative Research Thoughts, 14(9), b246-b253. https://ijcrt.org/viewpaperforall.php?paper=IJCRT2609130
MLA — 9th edition
Giri, Anku Kumar, et al. "CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS." International Journal of Creative Research Thoughts, vol. 14, no. 9, 2026, pp. b246-b253, https://ijcrt.org/viewpaperforall.php?paper=IJCRT2609130.
Chicago — 17th, bibliography
Giri, Anku Kumar, Rachna Bist, and Praveen Kumar. "CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS." International Journal of Creative Research Thoughts 14, no. 9 (2026): b246-b253. https://ijcrt.org/viewpaperforall.php?paper=IJCRT2609130.
Harvard — author–date
Giri, A.K., Bist, R. and Kumar, P. (2026) 'CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS', International Journal of Creative Research Thoughts, 14(9), pp. b246-b253. Available at: https://ijcrt.org/viewpaperforall.php?paper=IJCRT2609130
IEEE — numbered reference
A. K. Giri, R. Bist and P. Kumar, "CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS," IJCRT, vol. 14, no. 9, pp. b246-b253, Sep. 2026.
Vancouver — biomedical
Giri AK, Bist R, Kumar P. CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS. IJCRT. 2026 Sep;14(9):b246-b253.
AMA — 11th edition
Giri AK, Bist R, Kumar P. CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS. IJCRT. 2026;14(9):b246-b253. Accessed at https://ijcrt.org/viewpaperforall.php?paper=IJCRT2609130
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT2609130, author = {Anku Kumar Giri and Rachna Bist and Praveen Kumar}, title = {CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS}, journal = {International Journal of Creative Research Thoughts}, volume = {14}, number = {9}, pages = {b246-b253}, year = {2026}, month = {September}, issn = {2320-2882}, url = {https://ijcrt.org/viewpaperforall.php?paper=IJCRT2609130} }
RIS — EndNote, RefWorks
TY - JOUR AU - Giri, Anku Kumar AU - Bist, Rachna AU - Kumar, Praveen TI - CLINICAL INSIGHT ON MONO AND MULTI-DRUG APPROACHES IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS T2 - International Journal of Creative Research Thoughts JA - IJCRT VL - 14 IS - 9 PY - 2026 SN - 2320-2882 UR - https://ijcrt.org/viewpaperforall.php?paper=IJCRT2609130 SP - b246-b253 ER -

Issue

Volume 14 Issue 9, September-2026
Pages : b246-b253

Article Information

Pages
b246-b253
Published
September 2026
Registration ID
IJCRT_304391
Published Paper ID
IJCRT2609130
Research Area
Pharmacy All
Author Type
Indian Author
Location
Bettiah, Bihar, India
Licence
CC BY 4.0 · Open Access
ISSN & Impact Factor
2320-2882 · IF 9.17
Downloads
188

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International Journal of Creative Research Thoughts Published by IJCRT Publication
2320-2882 ISSN
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© 2026 — Authors hold the copyright of this article. This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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Declarations

Funding

No external funding was received for this study.

Conflict of Interest

The authors declare that they have no conflict of interest.

Acknowledgements

The authors would like to thank the reviewers and the editorial board of International Journal of Creative Research Thoughts for their careful reading and constructive comments, and all colleagues who supported the preparation of this manuscript.

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