ISSN2320-2882
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Paper Title

A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS)

Authors

Bhagyashri Laxman Gore , Pooja Muthyamraj Battul , Pratiksha Siddheshwar Bagade , Suhas Lalsing Chavan , Dipali Vilas Chavan

Keywords

Chronotherapy, Circadian rhythm, Pulsatile drug delivery, Lag time, Time-controlled release, Chrono pharmaceutics.

Abstract

Chronotherapeutic drug delivery systems (CDDS) are designed to synchronize drug release with the body's biological rhythms to optimize therapeutic outcomes. Numerous pathological conditions such as asthma, hypertension, rheumatoid arthritis, peptic ulcer disease, and cardiovascular disorders exhibit circadian variation in symptom severity. Conventional dosage forms fail to accommodate these temporal changes, often leading to suboptimal efficacy or increased adverse effects. CDDS aim to provide time-programmed, pulsatile, or site-specific drug release corresponding to disease rhythm. This review highlights the biological basis of chronotherapy, formulation strategies, advanced technologies, evaluation parameters, marketed products, and future research directions. The integration of chronobiology with modern pharmaceutical engineering offers promising opportunities for personalized medicine.

How To Cite

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IJCRT — journal style
"A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS)", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.14, Issue 3, page no.a381-a386, March 2026, Available :https://ijcrt.org/papers/IJCRT2603049.pdf
APA — 7th edition
Gore, B. L., Battul, P. M., Bagade, P. S., Chavan, S. L., & Chavan, D. V. (2026). A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS). International Journal of Creative Research Thoughts, 14(3), a381-a386. https://ijcrt.org/viewpaperforall.php?paper=IJCRT2603049
MLA — 9th edition
Gore, Bhagyashri Laxman, et al. "A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS)." International Journal of Creative Research Thoughts, vol. 14, no. 3, 2026, pp. a381-a386, https://ijcrt.org/viewpaperforall.php?paper=IJCRT2603049.
Chicago — 17th, bibliography
Gore, Bhagyashri Laxman, et al. "A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS)." International Journal of Creative Research Thoughts 14, no. 3 (2026): a381-a386. https://ijcrt.org/viewpaperforall.php?paper=IJCRT2603049.
Harvard — author–date
Gore, B.L. et al. (2026) 'A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS)', International Journal of Creative Research Thoughts, 14(3), pp. a381-a386. Available at: https://ijcrt.org/viewpaperforall.php?paper=IJCRT2603049
IEEE — numbered reference
B. L. Gore, P. M. Battul, P. S. Bagade, S. L. Chavan and D. V. Chavan, "A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS)," IJCRT, vol. 14, no. 3, pp. a381-a386, Mar. 2026.
Vancouver — biomedical
Gore BL, Battul PM, Bagade PS, Chavan SL, Chavan DV. A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS). IJCRT. 2026 Mar;14(3):a381-a386.
AMA — 11th edition
Gore BL, Battul PM, Bagade PS, Chavan SL, Chavan DV. A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS). IJCRT. 2026;14(3):a381-a386. Accessed at https://ijcrt.org/viewpaperforall.php?paper=IJCRT2603049
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT2603049, author = {Bhagyashri Laxman Gore and Pooja Muthyamraj Battul and Pratiksha Siddheshwar Bagade and Suhas Lalsing Chavan and Dipali Vilas Chavan}, title = {A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS)}, journal = {International Journal of Creative Research Thoughts}, volume = {14}, number = {3}, pages = {a381-a386}, year = {2026}, month = {March}, issn = {2320-2882}, url = {https://ijcrt.org/viewpaperforall.php?paper=IJCRT2603049} }
RIS — EndNote, RefWorks
TY - JOUR AU - Gore, Bhagyashri Laxman AU - Battul, Pooja Muthyamraj AU - Bagade, Pratiksha Siddheshwar AU - Chavan, Suhas Lalsing AU - Chavan, Dipali Vilas TI - A Comprehensive Review: Chronotherapeutic Drug Delivery System (CDDS) T2 - International Journal of Creative Research Thoughts JA - IJCRT VL - 14 IS - 3 PY - 2026 SN - 2320-2882 UR - https://ijcrt.org/viewpaperforall.php?paper=IJCRT2603049 SP - a381-a386 ER -

Issue

Volume 14 Issue 3, March-2026
Pages : a381-a386

Article Information

Pages
a381-a386
Published
March 2026
Registration ID
IJCRT_302311
Published Paper ID
IJCRT2603049
Research Area
Humanities All
Author Type
Indian Author
Location
Lohara ,Dist -Osmanabad, Maharashtra, India
Licence
CC BY 4.0 · Open Access
ISSN & Impact Factor
2320-2882 · IF 9.17
Downloads
156

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About Publisher

International Journal of Creative Research Thoughts Published by IJCRT Publication
2320-2882 ISSN
9.17 Impact Factor
2013 ESTD Year
Open Access
Impact Factor 9.17, calculated from Google Scholar citation data — see how it is worked out.
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Licence

© 2026 — Authors hold the copyright of this article. This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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Declarations

Funding

No external funding was received for this study.

Conflict of Interest

The authors declare that they have no conflict of interest.

Acknowledgements

The authors would like to thank the reviewers and the editorial board of International Journal of Creative Research Thoughts for their careful reading and constructive comments, and all colleagues who supported the preparation of this manuscript.

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