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Paper Title
Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model
Authors
Miss. Megha Yadav , Miss. Yashika Patel , Miss. Blessi N. Uikey , Dr. Rohit Seth , Dr. Ajay Amit
Keywords
Diazepam, Drug abuse, Drug toxicity, Drug dependency, Bone health
Abstract
Diazepam (Dz) is considered to be very safe initially, but later on it has been revealed that it may cause dependency. Since Dz is a drug of abuse, too, it may also cause intentional dependency. This intentional dependency is more serious due to the undefined nature of Dz consumption (Dose and frequency) and subsequent possible toxicity, which are generally not associated with therapeutic use of Dz. To evaluate the cellular toxic impact of Dz abuse, this study aimed to assess the impact of the number of defined overdoses of Dz on the cellular level of established enzyme markers for toxicity, i.e. TRAP-5b, ALT, AST, LDH and GST in the Swiss albino mice model. This study is unique as it monitors the serum level of these enzymes at various time intervals after discontinuation of Dz overdosing. The results of this study established a link between the number of Dz overdoses and irregularities in the serum levels of enzymes. It has been observed that the appearance of irregularities in the serum level of the chosen enzymes has been delayed after discontinuation of Dz abuse. Additionally, it is also evident that the persistence of this abnormality in the serum level of enzymes may depend on the number of doses of Dz (the higher the number of Dz overdoses, the longer the persistence of abnormalities). These irregularities are directly linked to Dz abuse with cellular toxicity as well as bone health.
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IJCRT — journal style
"Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.14, Issue 1, page no.f545-f555, January 2026, Available :https://ijcrt.org/papers/IJCRT2601685.pdf
APA — 7th edition
Yadav, M. M., Patel, M. Y., Uikey, M. B. N., Seth, R., & Amit, A. (2026). Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model. International Journal of Creative Research Thoughts, 14(1), f545-f555. https://doi.org/10.56975/ijcrt.v14i1.300782
MLA — 9th edition
Yadav, Miss. Megha, et al. "Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model." International Journal of Creative Research Thoughts, vol. 14, no. 1, 2026, pp. f545-f555, https://doi.org/10.56975/ijcrt.v14i1.300782.
Chicago — 17th, bibliography
Yadav, Miss. Megha, et al. "Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model." International Journal of Creative Research Thoughts 14, no. 1 (2026): f545-f555. https://doi.org/10.56975/ijcrt.v14i1.300782.
Harvard — author–date
Yadav, M.M. et al. (2026) 'Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model', International Journal of Creative Research Thoughts, 14(1), pp. f545-f555. Available at: https://doi.org/10.56975/ijcrt.v14i1.300782
IEEE — numbered reference
M. M. Yadav, M. Y. Patel, M. B. N. Uikey, R. Seth and A. Amit, "Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model," IJCRT, vol. 14, no. 1, pp. f545-f555, Jan. 2026, doi: 10.56975/ijcrt.v14i1.300782.
Vancouver — biomedical
Yadav MM, Patel MY, Uikey MBN, Seth R, Amit A. Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model. IJCRT. 2026 Jan;14(1):f545-f555. doi: 10.56975/ijcrt.v14i1.300782
AMA — 11th edition
Yadav MM, Patel MY, Uikey MBN, Seth R, Amit A. Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model. IJCRT. 2026;14(1):f545-f555. doi:10.56975/ijcrt.v14i1.300782
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT2601685,
author = {Miss. Megha Yadav and Miss. Yashika Patel and Miss. Blessi N. Uikey and Rohit Seth and Ajay Amit},
title = {Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model},
journal = {International Journal of Creative Research Thoughts},
volume = {14},
number = {1},
pages = {f545-f555},
year = {2026},
month = {January},
issn = {2320-2882},
doi = {10.56975/ijcrt.v14i1.300782},
url = {https://doi.org/10.56975/ijcrt.v14i1.300782}
}
RIS — EndNote, RefWorks
TY - JOUR
AU - Yadav, Miss. Megha
AU - Patel, Miss. Yashika
AU - Uikey, Miss. Blessi N.
AU - Seth, Rohit
AU - Amit, Ajay
TI - Time-Dependent Assessment of Diazepam Overdosing on Serum Levels of Marker Enzymes of Toxicity in a Mice Model
T2 - International Journal of Creative Research Thoughts
JA - IJCRT
VL - 14
IS - 1
PY - 2026
SN - 2320-2882
DO - 10.56975/ijcrt.v14i1.300782
UR - https://doi.org/10.56975/ijcrt.v14i1.300782
SP - f545-f555
ER -
Issue
Volume 14 Issue 1,
January-2026
Pages : f545-f555
Article Information
- Pages
- f545-f555
- Published
- January 2026
- Registration ID
- IJCRT_300782
- Published Paper ID
- IJCRT2601685
- Research Area
- Science All
- Author Type
- Indian Author
- Location
- Bilaspur, Chhattisgarh, India
- Peer Review
- Request Peer Review Report
- Licence
- CC BY 4.0 · Open Access
- ISSN & Impact Factor
- 2320-2882 · IF 9.17
- Downloads
- 237
- Permanent Link
- https://ijcrt.org/viewpaperforall.php?paper=IJCRT2601685
- Published Paper PDF
- https://ijcrt.org/papers/IJCRT2601685.pdf
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The authors would like to thank the reviewers and the editorial board of International Journal of Creative Research Thoughts for their careful reading and constructive comments, and all colleagues who supported the preparation of this manuscript.
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