ISSN2320-2882
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Paper Title

Exosomes based therapies in periodontitis: a new frontier

Authors

Fathima. K , Shivani. S , Dr. Nimisha mithradas , Dr. T. A. Lalitha , Dr. Navina ravindran

Keywords

Exosome, stem cells, periodontitis, periodontal regeneration, mesenchymal stem cells

Abstract

Periodontitis is defined as an inflammatory disease, initiated by bacteria, that results in the destruction of the supporting tissues of the teeth. Among the periodontal diseases, periodontitis remains one of the leading cause which is characterised by chronic inflammation and progressive destruction of the supporting structures of the teeth. Traditional treatment therapy to eradicate the cause are supra-gingival scaling, sub-gingival curettage and root planning. These therapies focus on mechanical debridement and anti-infective strategies. Exosomes play a vital role in tissue regeneration. Exosomes are small extra cellular vesicles which are secreted by various cell types. Exosomes are of two types natural exosomes and engineered exosomes. Exosomes are secreted by almost all cells, including mesenchymal stem cells(MSCs), periodontal ligament stem cells(PDLSCs), dendritic cells(DCs), B cells, T cells and mast cells. Exosomes derived from mesenchymal stem cells show higher potential ability in the regeneration of alveolar bone, periodontal ligament and cementum. Mesenchymal stem cells have healing and immunomodulatory properties which allows them to be widely used in the field of medicine. The common source of MSCs are bone marrow(BM-MSCs), dental pulp(DPSCs), periodontal ligament(PDLSCs) and gingiva(GMSCs). The use of Exosome-based strategies in medicine and dentistry is associated due to their high potential.

How To Cite

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IJCRT — journal style
"Exosomes based therapies in periodontitis: a new frontier", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.13, Issue 12, page no.f373-f381, December 2025, Available :https://ijcrt.org/papers/IJCRT2512607.pdf
APA — 7th edition
K, F., S, S., mithradas, N., Lalitha, T. A., & ravindran, N. (2025). Exosomes based therapies in periodontitis: a new frontier. International Journal of Creative Research Thoughts, 13(12), f373-f381. https://ijcrt.org/viewpaperforall.php?paper=IJCRT2512607
MLA — 9th edition
K, Fathima., et al. "Exosomes based therapies in periodontitis: a new frontier." International Journal of Creative Research Thoughts, vol. 13, no. 12, 2025, pp. f373-f381, https://ijcrt.org/viewpaperforall.php?paper=IJCRT2512607.
Chicago — 17th, bibliography
K, Fathima., et al. "Exosomes based therapies in periodontitis: a new frontier." International Journal of Creative Research Thoughts 13, no. 12 (2025): f373-f381. https://ijcrt.org/viewpaperforall.php?paper=IJCRT2512607.
Harvard — author–date
K, F. et al. (2025) 'Exosomes based therapies in periodontitis: a new frontier', International Journal of Creative Research Thoughts, 13(12), pp. f373-f381. Available at: https://ijcrt.org/viewpaperforall.php?paper=IJCRT2512607
IEEE — numbered reference
F. K, S. S, N. mithradas, T. A. Lalitha and N. ravindran, "Exosomes based therapies in periodontitis: a new frontier," IJCRT, vol. 13, no. 12, pp. f373-f381, Dec. 2025.
Vancouver — biomedical
K F, S S, mithradas N, Lalitha TA, ravindran N. Exosomes based therapies in periodontitis: a new frontier. IJCRT. 2025 Dec;13(12):f373-f381.
AMA — 11th edition
K F, S S, mithradas N, Lalitha TA, ravindran N. Exosomes based therapies in periodontitis: a new frontier. IJCRT. 2025;13(12):f373-f381. Accessed at https://ijcrt.org/viewpaperforall.php?paper=IJCRT2512607
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT2512607, author = {Fathima. K and Shivani. S and Nimisha mithradas and T. A. Lalitha and Navina ravindran}, title = {Exosomes based therapies in periodontitis: a new frontier}, journal = {International Journal of Creative Research Thoughts}, volume = {13}, number = {12}, pages = {f373-f381}, year = {2025}, month = {December}, issn = {2320-2882}, url = {https://ijcrt.org/viewpaperforall.php?paper=IJCRT2512607} }
RIS — EndNote, RefWorks
TY - JOUR AU - K, Fathima. AU - S, Shivani. AU - mithradas, Nimisha AU - Lalitha, T. A. AU - ravindran, Navina TI - Exosomes based therapies in periodontitis: a new frontier T2 - International Journal of Creative Research Thoughts JA - IJCRT VL - 13 IS - 12 PY - 2025 SN - 2320-2882 UR - https://ijcrt.org/viewpaperforall.php?paper=IJCRT2512607 SP - f373-f381 ER -

Issue

Volume 13 Issue 12, December-2025
Pages : f373-f381

Article Information

Pages
f373-f381
Published
December 2025
Registration ID
IJCRT_299009
Published Paper ID
IJCRT2512607
Research Area
Humanities All
Author Type
Indian Author
Location
Chennai, Tamil Nadu, India
Licence
CC BY 4.0 · Open Access
ISSN & Impact Factor
2320-2882 · IF 9.17
Downloads
166

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About Publisher

International Journal of Creative Research Thoughts Published by IJCRT Publication
2320-2882 ISSN
9.17 Impact Factor
2013 ESTD Year
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Impact Factor 9.17, calculated from Google Scholar citation data — see how it is worked out.
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Licence

© 2025 — Authors hold the copyright of this article. This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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Declarations

Funding

No external funding was received for this study.

Conflict of Interest

The authors declare that they have no conflict of interest.

Acknowledgements

The authors would like to thank the reviewers and the editorial board of International Journal of Creative Research Thoughts for their careful reading and constructive comments, and all colleagues who supported the preparation of this manuscript.

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