ISSN2320-2882
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Paper Title
Comparative studies between clobazam and Carbamazepine
Authors
Gondaliya Isha
Keywords
Clobazam, Carbamazepine, Lennox-Gastaut syndrome, Focal seizures, Generalized Tonic-Clonic seizures, Side effect profile, Anticonvulsant therapy, Neuropharmacology.
Abstract
Epilepsy, including syndromes like Lennox-Gastaut syndrome (LGS), focal seizures, and generalized tonic-clonic seizures, requires tailored anticonvulsant therapies to optimize efficacy and minimize adverse effects. This comprehensive review compares clobazam, a 1,5-benzodiazepine that enhances GABAergic neurotransmission with reduced sedation (Sankar, 2012; Gauthier & Mattson, 2015), and carbamazepine, a sodium channel blocker effective for partial and tonic-clonic seizures but associated with enzyme induction and cutaneous risks (French, 1994; Kehoe & Haw, 2020). Drawing from pharmacological, clinical, and neuropharmacological data, the analysis evaluates their physical and chemical properties, modes of action, advantages (e.g., clobazam's long-term efficacy in LGS; carbamazepine's versatility in neuropathic pain), disadvantages (e.g., clobazam's dependence risk; carbamazepine's hematologic toxicity), side effect profiles, toxicity (including teratogenicity), withdrawal symptoms, age-specific usage, and non-anticonvulsant applications (e.g., clobazam for anxiety; carbamazepine for bipolar disorder). Findings indicate clobazam offers a favorable safety profile for refractory pediatric epilepsy (Klehm et al., 2014), while carbamazepine excels in focal seizures but demands monitoring for interactions (Marson et al., 2002). Personalized treatment, considering patient age, seizure type, and comorbidities, is recommended to enhance quality of life and adherence (Samanta, 2021; Strzelczyk & Schubert-Bast, 2022). Future research should address gaps in long-term comparative trials.
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IJCRT — journal style
"Comparative studies between clobazam and Carbamazepine", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.13, Issue 12, page no.d394-d418, December 2025, Available :https://ijcrt.org/papers/IJCRT2512390.pdf
APA — 7th edition
Isha, G. (2025). Comparative studies between clobazam and Carbamazepine. International Journal of Creative Research Thoughts, 13(12), d394-d418. https://doi.org/10.56975/ijcrt.v13i12.296524
MLA — 9th edition
Isha, Gondaliya. "Comparative studies between clobazam and Carbamazepine." International Journal of Creative Research Thoughts, vol. 13, no. 12, 2025, pp. d394-d418, https://doi.org/10.56975/ijcrt.v13i12.296524.
Chicago — 17th, bibliography
Isha, Gondaliya. "Comparative studies between clobazam and Carbamazepine." International Journal of Creative Research Thoughts 13, no. 12 (2025): d394-d418. https://doi.org/10.56975/ijcrt.v13i12.296524.
Harvard — author–date
Isha, G. (2025) 'Comparative studies between clobazam and Carbamazepine', International Journal of Creative Research Thoughts, 13(12), pp. d394-d418. Available at: https://doi.org/10.56975/ijcrt.v13i12.296524
IEEE — numbered reference
G. Isha, "Comparative studies between clobazam and Carbamazepine," IJCRT, vol. 13, no. 12, pp. d394-d418, Dec. 2025, doi: 10.56975/ijcrt.v13i12.296524.
Vancouver — biomedical
Isha G. Comparative studies between clobazam and Carbamazepine. IJCRT. 2025 Dec;13(12):d394-d418. doi: 10.56975/ijcrt.v13i12.296524
AMA — 11th edition
Isha G. Comparative studies between clobazam and Carbamazepine. IJCRT. 2025;13(12):d394-d418. doi:10.56975/ijcrt.v13i12.296524
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT2512390,
author = {Gondaliya Isha},
title = {Comparative studies between clobazam and Carbamazepine},
journal = {International Journal of Creative Research Thoughts},
volume = {13},
number = {12},
pages = {d394-d418},
year = {2025},
month = {December},
issn = {2320-2882},
doi = {10.56975/ijcrt.v13i12.296524},
url = {https://doi.org/10.56975/ijcrt.v13i12.296524}
}
RIS — EndNote, RefWorks
TY - JOUR
AU - Isha, Gondaliya
TI - Comparative studies between clobazam and Carbamazepine
T2 - International Journal of Creative Research Thoughts
JA - IJCRT
VL - 13
IS - 12
PY - 2025
SN - 2320-2882
DO - 10.56975/ijcrt.v13i12.296524
UR - https://doi.org/10.56975/ijcrt.v13i12.296524
SP - d394-d418
ER -
Issue
Volume 13 Issue 12,
December-2025
Pages : d394-d418
Article Information
- Published In
- International Journal of Creative Research Thoughts — Volume 13, Issue 12, December 2025
- Pages
- d394-d418
- Published
- December 2025
- Registration ID
- IJCRT_296524
- Published Paper ID
- IJCRT2512390
- Research Area
- Pharmacy All
- Author Type
- Indian Author
- Location
- bhavnagar, gujarat, India
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- Request Peer Review Report
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- CC BY 4.0 · Open Access
- ISSN & Impact Factor
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- Published Paper PDF
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