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Paper Title

Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis

Authors

Dr. Unni Raja B , Dr. Rahul R K , Dr. Aswathy M , Dr. Aswathy H V

Keywords

Yoga, Rheumatoid arthritis, Inflammation, Anti-inflammatory

Abstract

Background: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease significantly impacting patients' quality of life and functional capacity. While conventional disease-modifying anti-rheumatic drugs (DMARDs) remain the cornerstone of treatment, complementary interventions like yoga have gained attention for their potential therapeutic benefits. Objective: To systematically review and analyze the effects of yoga-based interventions on clinical, immunological, and molecular outcomes in patients with rheumatoid arthritis. Methods: A comprehensive search was conducted following PRISMA 2020 guidelines. Four randomized controlled trials (RCTs) involving 331 participants with rheumatoid arthritis were included. Studies evaluated yoga interventions ranging from 8 to 12 weeks compared to usual care or educational control groups. Primary outcomes included disease activity scores (DAS28-ESR), health-related quality of life measures, and various biomarkers. Data synthesis was performed using standardized mean differences with 95% confidence intervals. Results: Meta-analysis revealed significant improvements in disease activity (pooled SMD: -0.52, 95% CI: -0.78 to -0.26, p < 0.001) and fatigue scores (SMD: -0.48, 95% CI: -0.72 to -0.24, p < 0.001). Yoga interventions demonstrated beneficial effects on inflammatory markers, including IL-6, IL-17, and TNF-?, while enhancing anti-inflammatory cytokines like TGF-? and IL-10. Molecular analyses revealed improved mitochondrial function, normalized T cell populations, and favorable gene expression patterns. Conclusions: Yoga-based interventions show promise as adjunctive therapy for rheumatoid arthritis, with evidence supporting improvements in disease activity, fatigue, and immune function. However, the limited number of studies and moderate quality of evidence necessitate further high-quality randomized controlled trials to establish definitive clinical recommendations.

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IJCRT — journal style
"Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.13, Issue 9, page no.e426-e437, September 2025, Available :https://ijcrt.org/papers/IJCRT2509509.pdf
APA — 7th edition
B, U. R., K, R. R., M, A., & V, A. H. (2025). Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis. International Journal of Creative Research Thoughts, 13(9), e426-e437. https://ijcrt.org/viewpaperforall.php?paper=IJCRT2509509
MLA — 9th edition
B, Unni Raja, et al. "Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis." International Journal of Creative Research Thoughts, vol. 13, no. 9, 2025, pp. e426-e437, https://ijcrt.org/viewpaperforall.php?paper=IJCRT2509509.
Chicago — 17th, bibliography
B, Unni Raja, et al. "Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis." International Journal of Creative Research Thoughts 13, no. 9 (2025): e426-e437. https://ijcrt.org/viewpaperforall.php?paper=IJCRT2509509.
Harvard — author–date
B, U.R. et al. (2025) 'Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis', International Journal of Creative Research Thoughts, 13(9), pp. e426-e437. Available at: https://ijcrt.org/viewpaperforall.php?paper=IJCRT2509509
IEEE — numbered reference
U. R. B, R. R. K, A. M and A. H. V, "Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis," IJCRT, vol. 13, no. 9, pp. e426-e437, Sep. 2025.
Vancouver — biomedical
B UR, K RR, M A, V AH. Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis. IJCRT. 2025 Sep;13(9):e426-e437.
AMA — 11th edition
B UR, K RR, M A, V AH. Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis. IJCRT. 2025;13(9):e426-e437. Accessed at https://ijcrt.org/viewpaperforall.php?paper=IJCRT2509509
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT2509509, author = {Unni Raja B and Rahul R K and Aswathy M and Aswathy H V}, title = {Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis}, journal = {International Journal of Creative Research Thoughts}, volume = {13}, number = {9}, pages = {e426-e437}, year = {2025}, month = {September}, issn = {2320-2882}, url = {https://ijcrt.org/viewpaperforall.php?paper=IJCRT2509509} }
RIS — EndNote, RefWorks
TY - JOUR AU - B, Unni Raja AU - K, Rahul R AU - M, Aswathy AU - V, Aswathy H TI - Effects of Yoga-Based Interventions on Rheumatoid Arthritis Outcomes: Systematic Review and Meta-Analysis T2 - International Journal of Creative Research Thoughts JA - IJCRT VL - 13 IS - 9 PY - 2025 SN - 2320-2882 UR - https://ijcrt.org/viewpaperforall.php?paper=IJCRT2509509 SP - e426-e437 ER -

Issue

Volume 13 Issue 9, September-2025
Pages : e426-e437

Article Information

Pages
e426-e437
Published
September 2025
Registration ID
IJCRT_294157
Published Paper ID
IJCRT2509509
Research Area
Humanities All
Author Type
Indian Author
Location
Kanyakumari, Tamil Nadu, India
Licence
CC BY 4.0 · Open Access
ISSN & Impact Factor
2320-2882 · IF 9.17
Downloads
360

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© 2025 — Authors hold the copyright of this article. This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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Declarations

Funding

No external funding was received for this study.

Conflict of Interest

The authors declare that they have no conflict of interest.

Acknowledgements

The authors would like to thank the reviewers and the editorial board of International Journal of Creative Research Thoughts for their careful reading and constructive comments, and all colleagues who supported the preparation of this manuscript.

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