ISSN2320-2882
Impact Factor9.17
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ESTD2013
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Paper Title
Multiple system atrophy and it's implications in Neurodegenerative disorders
Authors
Divyanshi Mathur
Keywords
Multiple System Atrophy, neurodegeneration, ?-synuclein, biomarkers, MRI atrophy, parkinsonism
Abstract
Multiple System Atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder characterized by various combinations of autonomic dysfunction, parkinsonism, and cerebellar ataxia. While often misdiagnosed as Parkinson's disease (PD) or progressive supranuclear palsy (PSP), MSA follows a more aggressive course with distinctive neuropathology. This study aims to elucidate MSA's clinical heterogeneity and identify key biomarkers and pathological mechanisms underlying its progression. Through a combination of retrospective cohort analysis, cerebrospinal fluid (CSF) biomarker assays, neuroimaging review, and neuropathological examination, we investigate diagnostic accuracy, disease progression, and overlaps with other synucleinopathies. Results demonstrate that MSA patients exhibit distinct CSF ?-synuclein oligomer patterns, greater cerebellar atrophy on MRI, and more rapid autonomic decline compared to matched PD patients. These findings support the hypothesis that MSA represents a distinct alpha-synucleinopathy with unique neurodegenerative trajectories. Limitations include small sample size and retrospective design. We propose future longitudinal and multi-center studies to validate biomarkers and refine disease-modifying therapeutic targets.
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IJCRT — journal style
"Multiple system atrophy and it's implications in Neurodegenerative disorders", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.13, Issue 8, page no.f18-f24, August 2025, Available :https://ijcrt.org/papers/IJCRT2508569.pdf
APA — 7th edition
Mathur, D. (2025). Multiple system atrophy and it's implications in Neurodegenerative disorders. International Journal of Creative Research Thoughts, 13(8), f18-f24. https://ijcrt.org/viewpaperforall.php?paper=IJCRT2508569
MLA — 9th edition
Mathur, Divyanshi. "Multiple system atrophy and it's implications in Neurodegenerative disorders." International Journal of Creative Research Thoughts, vol. 13, no. 8, 2025, pp. f18-f24, https://ijcrt.org/viewpaperforall.php?paper=IJCRT2508569.
Chicago — 17th, bibliography
Mathur, Divyanshi. "Multiple system atrophy and it's implications in Neurodegenerative disorders." International Journal of Creative Research Thoughts 13, no. 8 (2025): f18-f24. https://ijcrt.org/viewpaperforall.php?paper=IJCRT2508569.
Harvard — author–date
Mathur, D. (2025) 'Multiple system atrophy and it's implications in Neurodegenerative disorders', International Journal of Creative Research Thoughts, 13(8), pp. f18-f24. Available at: https://ijcrt.org/viewpaperforall.php?paper=IJCRT2508569
IEEE — numbered reference
D. Mathur, "Multiple system atrophy and it's implications in Neurodegenerative disorders," IJCRT, vol. 13, no. 8, pp. f18-f24, Aug. 2025.
Vancouver — biomedical
Mathur D. Multiple system atrophy and it's implications in Neurodegenerative disorders. IJCRT. 2025 Aug;13(8):f18-f24.
AMA — 11th edition
Mathur D. Multiple system atrophy and it's implications in Neurodegenerative disorders. IJCRT. 2025;13(8):f18-f24. Accessed at https://ijcrt.org/viewpaperforall.php?paper=IJCRT2508569
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT2508569,
author = {Divyanshi Mathur},
title = {Multiple system atrophy and it's implications in Neurodegenerative disorders},
journal = {International Journal of Creative Research Thoughts},
volume = {13},
number = {8},
pages = {f18-f24},
year = {2025},
month = {August},
issn = {2320-2882},
url = {https://ijcrt.org/viewpaperforall.php?paper=IJCRT2508569}
}
RIS — EndNote, RefWorks
TY - JOUR
AU - Mathur, Divyanshi
TI - Multiple system atrophy and it's implications in Neurodegenerative disorders
T2 - International Journal of Creative Research Thoughts
JA - IJCRT
VL - 13
IS - 8
PY - 2025
SN - 2320-2882
UR - https://ijcrt.org/viewpaperforall.php?paper=IJCRT2508569
SP - f18-f24
ER -
Issue
Volume 13 Issue 8,
August-2025
Pages : f18-f24
Article Information
- Pages
- f18-f24
- Published
- August 2025
- Registration ID
- IJCRT_292797
- Published Paper ID
- IJCRT2508569
- Research Area
- Others area
- Author Type
- Indian Author
- Location
- Ajmer, Rajasthan, India
- Peer Review
- Request Peer Review Report
- Licence
- CC BY 4.0 · Open Access
- ISSN & Impact Factor
- 2320-2882 · IF 9.17
- Downloads
- 236
- Permanent Link
- https://ijcrt.org/viewpaperforall.php?paper=IJCRT2508569
- Published Paper PDF
- https://ijcrt.org/papers/IJCRT2508569.pdf
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International Journal of Creative Research Thoughts
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The authors would like to thank the reviewers and the editorial board of International Journal of Creative Research Thoughts for their careful reading and constructive comments, and all colleagues who supported the preparation of this manuscript.
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