ISSN2320-2882
Impact Factor9.17
UGC ParametersAligned
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CrossRefDOI
ESTD2013
Peer ReviewTransparent
AccessOpen
Submission: Always Open
Paper Title
REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER.
Authors
Prasanna Kumar Panda , Gitanjali Mishra , Ruchi Bhattacharya , Ritika Singh , Ashish Kumar Netam3
Keywords
Keyword: Protein 53, invasive tumors, small cell cancer, anticancer activity, Cancer therapy.
Abstract
ABSTRACT:
Tumor Protein 53 or Protein 53 (P53) is the single most frequently altered gene in human cancers, with mutations being present in approximately 50% of all invasive tumors. However, in some of the most difficult-to-treat cancers such as high-grade serous ovarian cancers, triple-negative breast cancers, esophageal cancers, Small cell lungs cancers and squamous cell lung cancers, p53 is mutated in at least 80% of samples. Clearly, therefore, mutant p53 protein is an important candidate target against which new anticancer treatments could be developed. Although traditionally regarded as undruggable, several compounds such as p53 reactivation and induction of massive apoptosis-1 (PRIMA-1), a methylated derivative and structural analogue of PRIMA-1, i.e. APR-246, 2-sulfonylpyrimidines (PK11007), pyrazoles such as PK7088, zinc metallochaperone-1 (ZMC1), a third generation thiosemicarbazone developed by Critical Outcome Technologies Inc. (COTI-2) as well as specific peptides have recently been reported to reactive mutant p53 protein by converting it to a form exhibiting wild-type properties. Consistent with the reactivation of mutant p53, these compounds have been shown to exhibit anticancer activity in preclinical models expressing mutant p53.
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IJCRT — journal style
"REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER.", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.6, Issue 2, page no.390-400, April 2018, Available :https://ijcrt.org/papers/IJCRT1812050.pdf
APA — 7th edition
Panda, P. K., Mishra, G., Bhattacharya, R., Singh, R., & Netam3, A. K. (2018). REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER. International Journal of Creative Research Thoughts, 6(2), 390-400. https://ijcrt.org/viewpaperforall.php?paper=IJCRT1812050
MLA — 9th edition
Panda, Prasanna Kumar, et al. "REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER." International Journal of Creative Research Thoughts, vol. 6, no. 2, 2018, pp. 390-400, https://ijcrt.org/viewpaperforall.php?paper=IJCRT1812050.
Chicago — 17th, bibliography
Panda, Prasanna Kumar, et al. "REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER." International Journal of Creative Research Thoughts 6, no. 2 (2018): 390-400. https://ijcrt.org/viewpaperforall.php?paper=IJCRT1812050.
Harvard — author–date
Panda, P.K. et al. (2018) 'REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER', International Journal of Creative Research Thoughts, 6(2), pp. 390-400. Available at: https://ijcrt.org/viewpaperforall.php?paper=IJCRT1812050
IEEE — numbered reference
P. K. Panda, G. Mishra, R. Bhattacharya, R. Singh and A. K. Netam3, "REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER," IJCRT, vol. 6, no. 2, pp. 390-400, Mar. 2018.
Vancouver — biomedical
Panda PK, Mishra G, Bhattacharya R, Singh R, Netam3 AK. REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER. IJCRT. 2018 Mar;6(2):390-400.
AMA — 11th edition
Panda PK, Mishra G, Bhattacharya R, Singh R, Netam3 AK. REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER. IJCRT. 2018;6(2):390-400. Accessed at https://ijcrt.org/viewpaperforall.php?paper=IJCRT1812050
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT1812050,
author = {Prasanna Kumar Panda and Gitanjali Mishra and Ruchi Bhattacharya and Ritika Singh and Ashish Kumar Netam3},
title = {REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER.},
journal = {International Journal of Creative Research Thoughts},
volume = {6},
number = {2},
pages = {390-400},
year = {2018},
month = {March},
issn = {2320-2882},
url = {https://ijcrt.org/viewpaperforall.php?paper=IJCRT1812050}
}
RIS — EndNote, RefWorks
TY - JOUR
AU - Panda, Prasanna Kumar
AU - Mishra, Gitanjali
AU - Bhattacharya, Ruchi
AU - Singh, Ritika
AU - Netam3, Ashish Kumar
TI - REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER.
T2 - International Journal of Creative Research Thoughts
JA - IJCRT
VL - 6
IS - 2
PY - 2018
SN - 2320-2882
UR - https://ijcrt.org/viewpaperforall.php?paper=IJCRT1812050
SP - 390
EP - 400
ER -
Issue
Volume 6 Issue 2,
March-2018
Pages : 390-400
Article Information
- Pages
- 390-400
- Published
- March 2018
- Registration ID
- IJCRT_184229
- Published Paper ID
- IJCRT1812050
- Research Area
- Pharmacy
- Author Type
- Indian Author
- Location
- Raipur, Raipur, 493111
- Peer Review
- Request Peer Review Report
- Licence
- CC BY 4.0 · Open Access
- ISSN & Impact Factor
- 2320-2882 · IF 9.17
- Downloads
- 1,371
- Permanent Link
- https://ijcrt.org/viewpaperforall.php?paper=IJCRT1812050
- Published Paper PDF
- https://ijcrt.org/papers/IJCRT1812050.pdf
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International Journal of Creative Research Thoughts
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2320-2882
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