ISSN2320-2882
Impact Factor9.17
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ESTD2013
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Paper Title
A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE
Authors
Dr. Rakesh Kumar Godi
Keywords
Intratumor pH; extracellular pH; intracellular pH; intratumor pH con-trol mechanism; chemotherapy; radiotherapy; hyperthermia.
Abstract
The intratumor microenvironment is intrinsically acidic due mainly to accumulation of lactic acid as a result of increased aerobic and anaerobic glycolysis by the tumor cells. In general, the extracellular pH (pHe) in human tumors is below 7.0, whereas the intracellular pH (pHi) is maintained at neutral range, i.e., >7.0, by powerful pHi control mechanisms. The low pHe and the significant gradients between pHe and pHi affect markedly the response of tumors to various treatments such as chemotherapy, radio-therapy and hyperthermia. For instance, the acidic pHe increases the cellular uptake of weakly acidic drugs such as cyclophosphamide and cisplatin and thus increases the effect of the drugs, whereas the acidic pHe retards the uptake of weakly basic drug such as doxorubicin and vinblastine, thereby reducing the effect of the drugs. The radiation-induced apoptosis is suppressed by an acidic environment, whereas the hyperthermia-induced cell death is potentiated by an acidic environment. Better understanding of the control mechanisms of pHe and pHi in tumors may lead to device effective treatment strategy of human tumors.
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IJCRT — journal style
"A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE", IJCRT - International Journal of Creative Research Thoughts (www.ijcrt.org), ISSN:2320-2882, Vol.5, Issue 4, page no.455-475, October 2017, Available :https://ijcrt.org/papers/IJCRT1704062.pdf
APA — 7th edition
Godi, R. K. (2017). A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE. International Journal of Creative Research Thoughts, 5(4), 455-475. https://ijcrt.org/viewpaperforall.php?paper=IJCRT1704062
MLA — 9th edition
Godi, Rakesh Kumar. "A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE." International Journal of Creative Research Thoughts, vol. 5, no. 4, 2017, pp. 455-475, https://ijcrt.org/viewpaperforall.php?paper=IJCRT1704062.
Chicago — 17th, bibliography
Godi, Rakesh Kumar. "A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE." International Journal of Creative Research Thoughts 5, no. 4 (2017): 455-475. https://ijcrt.org/viewpaperforall.php?paper=IJCRT1704062.
Harvard — author–date
Godi, R.K. (2017) 'A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE', International Journal of Creative Research Thoughts, 5(4), pp. 455-475. Available at: https://ijcrt.org/viewpaperforall.php?paper=IJCRT1704062
IEEE — numbered reference
R. K. Godi, "A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE," IJCRT, vol. 5, no. 4, pp. 455-475, Oct. 2017.
Vancouver — biomedical
Godi RK. A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE. IJCRT. 2017 Oct;5(4):455-475.
AMA — 11th edition
Godi RK. A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE. IJCRT. 2017;5(4):455-475. Accessed at https://ijcrt.org/viewpaperforall.php?paper=IJCRT1704062
BibTeX — Zotero, Mendeley, LaTeX
@article{IJCRT1704062,
author = {Rakesh Kumar Godi},
title = {A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE},
journal = {International Journal of Creative Research Thoughts},
volume = {5},
number = {4},
pages = {455-475},
year = {2017},
month = {October},
issn = {2320-2882},
url = {https://ijcrt.org/viewpaperforall.php?paper=IJCRT1704062}
}
RIS — EndNote, RefWorks
TY - JOUR
AU - Godi, Rakesh Kumar
TI - A STUDY OF PHYSIOLOGICAL HOMEOSTASIS AND ITS INFLUENCE OF TUMOR PH ON THERAPEUTIC RESPONSE
T2 - International Journal of Creative Research Thoughts
JA - IJCRT
VL - 5
IS - 4
PY - 2017
SN - 2320-2882
UR - https://ijcrt.org/viewpaperforall.php?paper=IJCRT1704062
SP - 455
EP - 475
ER -
Issue
Volume 5 Issue 4,
October-2017
Pages : 455-475
Article Information
- Pages
- 455-475
- Published
- October 2017
- Registration ID
- IJCRT_170283
- Published Paper ID
- IJCRT1704062
- Research Area
- Medical Science
- Author Type
- Indian Author
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- Request Peer Review Report
- Licence
- CC BY 4.0 · Open Access
- ISSN & Impact Factor
- 2320-2882 · IF 9.17
- Downloads
- 1,538
- Permanent Link
- https://ijcrt.org/viewpaperforall.php?paper=IJCRT1704062
- Published Paper PDF
- https://ijcrt.org/papers/IJCRT1704062.pdf
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