Published Paper Details:

Nanoemulsions have emerged as advanced colloidal carriers capable of enhancing topical drug delivery by improving solubility, permeation, and therapeutic efficacy. Their nanoscale droplet size, high kinetic stability, and compatibility with diverse pharmaceutical actives make them ideal for dermatological and cosmeceutical applications. This review provides a comprehensive analysis of nanoemulsion formulation strategies, mechanistic insights into skin permeation, characterization techniques, and translational progress toward clinical use. Special emphasis is placed on nanoemulgels, surfactant/co-surfactant systems, droplet engineering, and therapeutic applications in inflammation, infection control, wound healing, and chronic skin diseases. Challenges related to scale-up, regulatory pathways, and long-term safety are critically evaluated. Future directions highlight personalized nanoemulsion therapy, multifunctional systems, and AI-driven formulation optimization.