Published Paper Details:

Wound Although the biological process of healing is intricate and tightly controlled, chronic and non-healing wounds continue to pose a significant clinical challenge, impacting millions of patients globally and putting a significant financial strain on healthcare systems. Prolonged inflammation, poor angiogenesis, oxidative stress, microbial colonization, and dysregulated protease activity are some of the factors that lead to delayed wound healing, especially in older and diabetic populations. Because of its strong anti-inflammatory, antibacterial, antioxidant, and pro-angiogenic qualities, velutin, a naturally occurring flavonoid, has garnered more and more interest for use in wound healing applications. Poor aqueous solubility, low absorption, and insufficient retention at the wound site hinder velutin's clinical translation despite its therapeutic potential. Thermosensitive hydrogels have emerged as an advanced drug delivery platform capable of overcoming these limitations by providing in situ gelation, sustained drug release, enhanced wound residence time, and a moist, protective healing environment. This review highlights the pathophysiology of chronic wounds, the pharmacological potential of velutin in wound repair, and the advantages of thermosensitive hydrogel systems as wound dressings. Emphasis is placed on the synergistic integration of velutin with thermoresponsive hydrogels as a promising strategy to improve therapeutic efficacy, patient compliance, and overall wound healing outcomes.