Published Paper Details:

The primary aim of the topic is to formulate and evaluate a phytosome-based topical gel containing extract of Black Turmeric (Curcuma caesia) and Cassia fistula with objective of enhancing phytoconstituent bioavailability and assessing its anti-inflammatory. The present study focuses on the formulation and evaluation of a phytosome-based topical herbal gel containing extracts of Black Turmeric (Curcuma caesia) and Cassia fistula for enhanced anti-inflammatory activity. Herbal extracts often show limited therapeutic effectiveness due to poor solubility and low bioavailability; therefore, phytosome technology using phospholipids such as soya lecithin was employed to improve their absorption and stability. The extracts were prepared using suitable extraction methods and formulated into phytosomes, which were then incorporated into a topical gel base. The prepared formulation was evaluated for parameters such as particle size, entrapment efficiency, pH, viscosity, spreadability, stability, and in vitro drug release. Black Turmeric possesses anti-inflammatory, antioxidant, and analgesic properties, while Cassia fistula is known for its anti-inflammatory and wound-healing effects. The phytosomal gel formulation is expected to improve bioavailability, enhance skin permeation, and provide better therapeutic efficacy compared to conventional herbal formulations .