Published Paper Details:

Abstract: Microbiomes : microbial communities exist consistently in or on living hosts, such as humans, animals, plants, in soil, water and air. The microbiome includes micoorganisms, like bacteria, fungi, viruses, and their genes. Microorganisms in microbiomes interact dynamically with their hosts and among themselves to form synergistic relationships. These interactions determine the composition of the microbiome and influence not only the features of the ecosystems where they reside, but can also have effects affecting the physiology of the hosts. The disease development is often correlated with microbial dysbiosis, or a shift in the microbiota. Gut dysbiosis may lead to Neurological, Gastrointestinal diseases, Celiac disease, Liver diseases, Allergies etc. Other reasons for dysbiosis and gut disorders are medications, unhealthy lifestyles, and genetic conditions. Current review focuses on studying effectiveness of Microbiome techniques in treating gut disorders as Microbiome engineering gaining more attention from few decades. Microbiome engineering probably applied most extensively on the human microbiome due to the potential of manipulating microbiota in humans for treatment of diseases. Allopathy often focuses on symptom suppression and acute intervention, while microbiome therapy aims to restore ecosystem (human) balance to address root causes. Microbiome techniques like Probiotoics, FMT, Phage therapy, omics studies are proving their effectiveness in treating the GI conditions. Engineering methods like FMT, Genetically engineered bacteria, prebiotic, probiotics are gaining success. Products like Rebyota, SER-109 / Vowst are successful for treatment of C. difficile infection. Although certain limitations of microbiome engineering are like poor Engraftment, Colonization Challenges & risks of altering the human microbiome detailed studies and research in combination with smart tools will lead to new trend in disease treatment. Microbiome techniques are thus effective, safe & have clinical applications in treating GI disorders.