Published Paper Details:

Ultrasound-responsive nanocarriers have emerged as a transformative approach for targeted and controlled drug delivery, offering spatiotemporal precision unattainable with conventional systems. Among these, bubble liposomes (BLs) lipid vesicles encapsulating gas or perfluorocarbon cores combine the biocompatibility of liposomes with the echogenicity of microbubbles, enabling both diagnostic imaging and therapeutic delivery. Exposure to ultrasound triggers bubble oscillation and cavitation, resulting in transient perturbation of the liposomal membrane and controlled release of encapsulated drugs, nucleic acids, or imaging agents at the target site. This theranostic functionality reduces systemic toxicity and enhances therapeutic efficacy. This review provides a comprehensive discussion on the structural features, classification, preparation methods, physicochemical factors, mechanisms of action, evaluation strategies, and applications of bubble liposomes. Additionally, the review examines current limitations and future opportunities in translating this technology to clinical use. By integrating imaging and therapy, BLs represent a novel paradigm in nanomedicine, bridging diagnostic and therapeutic modalities.