Published Paper Details:

The aim of the present study was to evaluate the protective role of vitamin C on Cypermethrin induced reproductive toxicity in male rats. Healthy 40 male rats were randomly divided into 5 groups with 8 animals each. Group I served as control and administered with saline and group II and III were administered with Cypermethrin at a dose of 50mg and 100mg/kg BW respectively. Group IV administered with vitamin C alone at a dose of 60mg/kg BW orally and group V administered with both Cypermethrin(100mg/kg BW) and vitamin C(60mg/kg BW)for 60 days. After the treatment rats were sacrificed and isolated the reproductive organs immediately for biochemical analysis. The body weights of rats did not show any significant change in all groups. Whereas the weights of reproductive organs were significantly decreased in Cypermethrin administered groups. Treatment with Cypermethrin significantly decreased epididymal sperm count, viable sperms and motile sperms with a significant reduction in the testicular steroidogenic enzymes (3?-HSD and 17 ? HSD) activities. Histoarchitechture of testis of rats administered with cypermethrin showed degenerative changes in seminiferous tubules with reduced size, increased interstitial spaces, and inhibited spermatogenesis. Where as co-administration of Vitamin C with Cypermethrin showed a significant improvement in the weights of reproductive organs, sperm count, sperm viability and motility. The co-treatment of vitamin C also significantly increased the activity levels of steroidogenic enzymes and it restored the structural integrity of testicular architecture in Cypermethrin intoxicated rats. The present study indicating the protective role of vitamin C against cypermethrin induced reproductive toxicity in male rats.